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dc.creatorStojičić, Sonja
dc.creatorMilutinović-Smiljanić, Sanja
dc.creatorSarenac, Olivera
dc.creatorŽivković, Slavoljub
dc.creatorJapundžić-Žigon, Nina
dc.date.accessioned2020-07-02T12:12:44Z
dc.date.available2020-07-02T12:12:44Z
dc.date.issued2006
dc.identifier.issn0013-5585
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1316
dc.description.abstractThis study investigates the contribution of central vasopressin receptors in the modulation of systolic arterial pressure (SAP) and heart rate (HR) response to air-jet stress in conscious Wistar rats equipped with a femoral arterial catheter and intracerebroventricular cannula using novel non-peptide and selective vasopressin V, (SR49059) and V-1b (SSR149415) antagonists. The effects of stress on SAP and HR were evaluated by measuring the maximal response to stress, the latency of the maximal response, the duration of the recovery period, and the increase in the low frequency (LF) short-term variability component. Stress induced a parallel and almost immediate increase in both SAP and HR, followed by enhanced LF SAP variability in the recovery period. Pretreatment of rats with V-1a antagonist did not affect the maximal increase or the latency of SAP and HR response to acute stress, but shortened the recovery period of SAP and HR and prevented the increase in LF SAP. The V-1b antagonist reduced the maximal increase in SAP without affecting HR and their latencies, shortened the recovery period of SAP and inhibited the increase in LF SAP variability. These results indicate that both central V-1a and V-1b receptors mediate cardiovascular changes induced by air-jet stress in conscious rats.en
dc.publisherWalter De Gruyter Gmbh, Berlin
dc.rightsrestrictedAccess
dc.sourceBiomedizinische Technik
dc.subjectblood pressureen
dc.subjectheart rateen
dc.subjectspectral analysisen
dc.titleCentral vasopressin V-1a and V-1b receptors modulate the cardiovascular response to air-jet stress in conscious ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојичић, Соња; Јапунджић-Жигон, Нина; Милутиновић-Смиљанић, Сања; Живковић, Славољуб; Саренац, Оливера;
dc.citation.volume51
dc.citation.issue4
dc.citation.spage268
dc.citation.epage271
dc.citation.other51(4): 268-271
dc.citation.rankM23
dc.identifier.wos000242008500044
dc.identifier.doi10.1515/BMT.2006.053
dc.identifier.pmid17061955
dc.identifier.scopus2-s2.0-34247207115
dc.type.versionpublishedVersion


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Приказ основних података о документу