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The role of central vasopressin receptors in the modulation of autonomic cardiovascular controls: a spectral analysis study
dc.creator | Milutinović-Smiljanić, Sanja | |
dc.creator | Murphy, David | |
dc.creator | Japundžić-Žigon, Nina | |
dc.date.accessioned | 2020-07-02T12:12:56Z | |
dc.date.available | 2020-07-02T12:12:56Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0363-6119 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1319 | |
dc.description.abstract | Although it has been suggested that vasopressin (VP) acts within the central nervous system to modulate autonomic cardiovascular controls, the mechanisms involved are not understood. Using nonpeptide, selective V-1a, V-1b, and V-2 antagonists, in conscious rats, we assessed the roles of central VP receptors, under basal conditions, after the central application of exogenous VP, and after immobilization, on cardiovascular short-term variability. Equidistant sampling of blood pressure (BP) and heart rate (HR) at 20 Hz allowed direct spectral analysis in very-low frequency (VLF-BP), low-frequency (LF-BP), and high-frequency (HF-BP) blood pressure domains. The effect of VP antagonists and of exogenous VP on body temperature (T-b) was also investigated. Under basal conditions, V-1a antagonist increased HF-BP and T-b, and this was prevented by metamizol. V-1b antagonist enhanced HF-BP without affecting T-b, and V-2 antagonist increased VLF-BP variability which could be prevented by quinapril. Immobilization increased BP, LF-BP, HF-BP, and HF-HR variability. V-1a antagonist prevented BP and HR variability changes induced by immobilization and potentiated tachycardia. V-1b antagonist prevented BP but not HR variability changes, whereas V-2 antagonist had no effect. Exogenous VP increased systolic arterial pressure ( SAP) and HF-SAP variability, and this was prevented by V-1a and V-1b but not V-2 antagonist pretreatment. Our results suggest that, under basal conditions, VP, by stimulation of V-1a, V-1b, and cognate V-2 receptors, buffers BP variability, mostly due to thermoregulation. Immobilization and exogenous V-P, by stimulation of V-1a or V-1b, but not V-2 receptors, increases BP variability, revealing cardiorespiratory adjustment to stress and respiratory stimulation, respectively. | en |
dc.publisher | Amer Physiological Soc, Bethesda | |
dc.rights | restrictedAccess | |
dc.source | American Journal of Physiology - Regulatory Integrative & Comparative Physiology | |
dc.subject | temperature | en |
dc.subject | heart rate | en |
dc.subject | V-1a | en |
dc.subject | V-1b | en |
dc.subject | V-2 antagonist | en |
dc.title | The role of central vasopressin receptors in the modulation of autonomic cardiovascular controls: a spectral analysis study | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јапунджић-Жигон, Нина; Мурпхy, Давид; Милутиновић-Смиљанић, Сања; | |
dc.citation.volume | 291 | |
dc.citation.issue | 6 | |
dc.citation.spage | R1579 | |
dc.citation.epage | R1591 | |
dc.citation.other | 291(6): R1579-R1591 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000241768400002 | |
dc.identifier.doi | 10.1152/ajpregu.00764.2005 | |
dc.identifier.pmid | 17085750 | |
dc.identifier.scopus | 2-s2.0-33845403130 | |
dc.type.version | publishedVersion |