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Bcl-2 expression in oral squamous cell carcinoma

Authorized Users Only
2007
Authors
Popović, Branka
Jekić, B.
Novaković, I.
Luković, Ljiljana
Tepavčević, Zvezdana
Jurišić, Vladimir
Vukadinović, Miroslav
Milašin, Jelena
Article (Published version)
Metadata
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Abstract
Apoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positivel...y stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic].

Source:
Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease, 2007, 1095, 19-25
Publisher:
  • Wiley-Blackwell, Hoboken

DOI: 10.1196/annals.1397.003

ISSN: 0077-8923

PubMed: 17404013

WoS: 000245947400003

Scopus: 2-s2.0-34247885909
[ Google Scholar ]
25
21
URI
https://smile.stomf.bg.ac.rs/handle/123456789/1329
Collections
  • Radovi istraživača
Institution/Community
Stomatološki fakultet
TY  - JOUR
AU  - Popović, Branka
AU  - Jekić, B.
AU  - Novaković, I.
AU  - Luković, Ljiljana
AU  - Tepavčević, Zvezdana
AU  - Jurišić, Vladimir
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1329
AB  - Apoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positively stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic].
PB  - Wiley-Blackwell, Hoboken
T2  - Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease
T1  - Bcl-2 expression in oral squamous cell carcinoma
VL  - 1095
SP  - 19
EP  - 25
DO  - 10.1196/annals.1397.003
ER  - 
@article{
author = "Popović, Branka and Jekić, B. and Novaković, I. and Luković, Ljiljana and Tepavčević, Zvezdana and Jurišić, Vladimir and Vukadinović, Miroslav and Milašin, Jelena",
year = "2007",
abstract = "Apoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positively stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic].",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease",
title = "Bcl-2 expression in oral squamous cell carcinoma",
volume = "1095",
pages = "19-25",
doi = "10.1196/annals.1397.003"
}
Popović, B., Jekić, B., Novaković, I., Luković, L., Tepavčević, Z., Jurišić, V., Vukadinović, M.,& Milašin, J.. (2007). Bcl-2 expression in oral squamous cell carcinoma. in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease
Wiley-Blackwell, Hoboken., 1095, 19-25.
https://doi.org/10.1196/annals.1397.003
Popović B, Jekić B, Novaković I, Luković L, Tepavčević Z, Jurišić V, Vukadinović M, Milašin J. Bcl-2 expression in oral squamous cell carcinoma. in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease. 2007;1095:19-25.
doi:10.1196/annals.1397.003 .
Popović, Branka, Jekić, B., Novaković, I., Luković, Ljiljana, Tepavčević, Zvezdana, Jurišić, Vladimir, Vukadinović, Miroslav, Milašin, Jelena, "Bcl-2 expression in oral squamous cell carcinoma" in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease, 1095 (2007):19-25,
https://doi.org/10.1196/annals.1397.003 . .

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