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dc.creatorPopović, Branka
dc.creatorJekić, B.
dc.creatorNovaković, I.
dc.creatorLuković, Ljiljana
dc.creatorTepavčević, Zvezdana
dc.creatorJurišić, Vladimir
dc.creatorVukadinović, Miroslav
dc.creatorMilašin, Jelena
dc.date.accessioned2020-07-02T12:13:35Z
dc.date.available2020-07-02T12:13:35Z
dc.date.issued2007
dc.identifier.issn0077-8923
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1329
dc.description.abstractApoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positively stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic].en
dc.publisherWiley-Blackwell, Hoboken
dc.rightsrestrictedAccess
dc.sourceSignal Transduction Pathways, Pt C: Cell Signaling in Health & Disease
dc.titleBcl-2 expression in oral squamous cell carcinomaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛуковић, Љиљана; Новаковић, И.; Јекић, Б.; Вукадиновић, Мирослав; Јуришић, Владимир; Поповић, Бранка; Милашин, Јелена; Тепавчевић, Звездана;
dc.citation.volume1095
dc.citation.spage19
dc.citation.epage25
dc.citation.other1095: 19-25
dc.citation.rankM21
dc.identifier.wos000245947400003
dc.identifier.doi10.1196/annals.1397.003
dc.identifier.pmid17404013
dc.identifier.scopus2-s2.0-34247885909
dc.type.versionpublishedVersion


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