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Bcl-2 expression in oral squamous cell carcinoma
dc.creator | Popović, Branka | |
dc.creator | Jekić, B. | |
dc.creator | Novaković, I. | |
dc.creator | Luković, Ljiljana | |
dc.creator | Tepavčević, Zvezdana | |
dc.creator | Jurišić, Vladimir | |
dc.creator | Vukadinović, Miroslav | |
dc.creator | Milašin, Jelena | |
dc.date.accessioned | 2020-07-02T12:13:35Z | |
dc.date.available | 2020-07-02T12:13:35Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0077-8923 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1329 | |
dc.description.abstract | Apoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positively stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic]. | en |
dc.publisher | Wiley-Blackwell, Hoboken | |
dc.rights | restrictedAccess | |
dc.source | Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease | |
dc.title | Bcl-2 expression in oral squamous cell carcinoma | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Луковић, Љиљана; Новаковић, И.; Јекић, Б.; Вукадиновић, Мирослав; Јуришић, Владимир; Поповић, Бранка; Милашин, Јелена; Тепавчевић, Звездана; | |
dc.citation.volume | 1095 | |
dc.citation.spage | 19 | |
dc.citation.epage | 25 | |
dc.citation.other | 1095: 19-25 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000245947400003 | |
dc.identifier.doi | 10.1196/annals.1397.003 | |
dc.identifier.pmid | 17404013 | |
dc.identifier.scopus | 2-s2.0-34247885909 | |
dc.type.version | publishedVersion |