Prevalence of Y chromosome microdeletions in infertile men with severe oligozoospermia in Serbia: Aim: The aim of this study was to determine the prevalence and type of microdeletions of the Y chromosome of men with severe oligozoospermia-ICSI candidates in the Serbian population and to compare our findings with those from other parts of the world. Methods: In all patients spermiogram has been performed in order to determine the sperm concentration. Patients were subjected to detailed clinical, endocrinological and cytogenetic examinations. Microdeletion analysis was performed by polymerase chain reaction (PCR) on 203 patients with normal cytogenetic findings. The STS markers tested in each case were sY84, sY86 (AZFa); sY127, sY134 (AZFb); sY254, sY255 (AZFc). Results: at least one of the STS markers was deleted in I I of the 203 cases (5.4 %). Conclusion: AZFc microdeletions were identified with a rather high prevalence in men with severe oligozoospermia ICSI candidates in Serbian pop...ulation.
Keywords:
severe oligozoospermia / male infertility / PCR / Y chromosome / microdeletion / ICSI
TY - JOUR
AU - Ristanović, M.
AU - Bunjevački, Vera
AU - Tulić, C.
AU - Novaković, I.
AU - Perović, V.
AU - Luković, Ljiljana
AU - Milašin, Jelena
PY - 2007
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1332
AB - Prevalence of Y chromosome microdeletions in infertile men with severe oligozoospermia in Serbia: Aim: The aim of this study was to determine the prevalence and type of microdeletions of the Y chromosome of men with severe oligozoospermia-ICSI candidates in the Serbian population and to compare our findings with those from other parts of the world. Methods: In all patients spermiogram has been performed in order to determine the sperm concentration. Patients were subjected to detailed clinical, endocrinological and cytogenetic examinations. Microdeletion analysis was performed by polymerase chain reaction (PCR) on 203 patients with normal cytogenetic findings. The STS markers tested in each case were sY84, sY86 (AZFa); sY127, sY134 (AZFb); sY254, sY255 (AZFc). Results: at least one of the STS markers was deleted in I I of the 203 cases (5.4 %). Conclusion: AZFc microdeletions were identified with a rather high prevalence in men with severe oligozoospermia ICSI candidates in Serbian population.
PB - Medecine Et Hygiene, Chene-Bourg
T2 - Genetic Counseling
T1 - Prevalence of Y chromosome microdeletions in infertile men with severe oligozoospermia in Serbia
VL - 18
IS - 3
SP - 337
EP - 342
UR - https://hdl.handle.net/21.15107/rcub_smile_1332
ER -
@article{
author = "Ristanović, M. and Bunjevački, Vera and Tulić, C. and Novaković, I. and Perović, V. and Luković, Ljiljana and Milašin, Jelena",
year = "2007",
abstract = "Prevalence of Y chromosome microdeletions in infertile men with severe oligozoospermia in Serbia: Aim: The aim of this study was to determine the prevalence and type of microdeletions of the Y chromosome of men with severe oligozoospermia-ICSI candidates in the Serbian population and to compare our findings with those from other parts of the world. Methods: In all patients spermiogram has been performed in order to determine the sperm concentration. Patients were subjected to detailed clinical, endocrinological and cytogenetic examinations. Microdeletion analysis was performed by polymerase chain reaction (PCR) on 203 patients with normal cytogenetic findings. The STS markers tested in each case were sY84, sY86 (AZFa); sY127, sY134 (AZFb); sY254, sY255 (AZFc). Results: at least one of the STS markers was deleted in I I of the 203 cases (5.4 %). Conclusion: AZFc microdeletions were identified with a rather high prevalence in men with severe oligozoospermia ICSI candidates in Serbian population.",
publisher = "Medecine Et Hygiene, Chene-Bourg",
journal = "Genetic Counseling",
title = "Prevalence of Y chromosome microdeletions in infertile men with severe oligozoospermia in Serbia",
volume = "18",
number = "3",
pages = "337-342",
url = "https://hdl.handle.net/21.15107/rcub_smile_1332"
}
Ristanović, M., Bunjevački, V., Tulić, C., Novaković, I., Perović, V., Luković, L.,& Milašin, J.. (2007). Prevalence of Y chromosome microdeletions in infertile men with severe oligozoospermia in Serbia. in Genetic Counseling
Medecine Et Hygiene, Chene-Bourg., 18(3), 337-342.
https://hdl.handle.net/21.15107/rcub_smile_1332
Ristanović M, Bunjevački V, Tulić C, Novaković I, Perović V, Luković L, Milašin J. Prevalence of Y chromosome microdeletions in infertile men with severe oligozoospermia in Serbia. in Genetic Counseling. 2007;18(3):337-342.
https://hdl.handle.net/21.15107/rcub_smile_1332 .
Ristanović, M., Bunjevački, Vera, Tulić, C., Novaković, I., Perović, V., Luković, Ljiljana, Milašin, Jelena, "Prevalence of Y chromosome microdeletions in infertile men with severe oligozoospermia in Serbia" in Genetic Counseling, 18, no. 3 (2007):337-342,
https://hdl.handle.net/21.15107/rcub_smile_1332 .
