The aim of our study was to investigate the expression of γ-catenin in normal kidney and in Wilms' tumor by immunohistochemistry and to correlate the results with tumor stage, histological type, and prognostic group. We investigated 28 cases of Wilms' tumor, 2 Wilms' tumor metastases in lungs, and 1 specimen of normal renal tissue. Expression of γ-catenin was detected in 14 cases. There was a weak inverse relationship between γ-catenin expression and tumor stage. Expression of γ-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative. In 2 metastatic cases and in the case of bilateral Wilms' tumor γ-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of γ-catenin and unfavorable outcome.
Keywords:
γ-catenin / Adhesion molecules / Histological type / Prognostic group / Tumor stage
Source:
Fetal & Pediatric Pathology, 2008, 27, 2, 63-70
Funding / projects:
This work was supported by the Ministry of Science, Technology and Development of Serbia. Address correspondence to Dejan Arsic, Children’s Cancer Research Group, Department of Paediatrics, Christchurch School of Medicine and Health Sciences
TY - JOUR
AU - Basta-Jovanović, Gordana
AU - Gvozdenović, E.
AU - Dimitrijević, I.
AU - Brašanac, Dimitrije
AU - Vučković, Mila
AU - Kalezić, Nevena
AU - Baralić, I.
AU - Radojević-Škodrić, Sanja
AU - Arsić, D.
PY - 2008
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1395
AB - The aim of our study was to investigate the expression of γ-catenin in normal kidney and in Wilms' tumor by immunohistochemistry and to correlate the results with tumor stage, histological type, and prognostic group. We investigated 28 cases of Wilms' tumor, 2 Wilms' tumor metastases in lungs, and 1 specimen of normal renal tissue. Expression of γ-catenin was detected in 14 cases. There was a weak inverse relationship between γ-catenin expression and tumor stage. Expression of γ-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative. In 2 metastatic cases and in the case of bilateral Wilms' tumor γ-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of γ-catenin and unfavorable outcome.
T2 - Fetal & Pediatric Pathology
T1 - Immunohistochemical analysis of gamma catenin in Wilms' tumors
VL - 27
IS - 2
SP - 63
EP - 70
DO - 10.1080/15513810802028704
ER -
@article{
author = "Basta-Jovanović, Gordana and Gvozdenović, E. and Dimitrijević, I. and Brašanac, Dimitrije and Vučković, Mila and Kalezić, Nevena and Baralić, I. and Radojević-Škodrić, Sanja and Arsić, D.",
year = "2008",
abstract = "The aim of our study was to investigate the expression of γ-catenin in normal kidney and in Wilms' tumor by immunohistochemistry and to correlate the results with tumor stage, histological type, and prognostic group. We investigated 28 cases of Wilms' tumor, 2 Wilms' tumor metastases in lungs, and 1 specimen of normal renal tissue. Expression of γ-catenin was detected in 14 cases. There was a weak inverse relationship between γ-catenin expression and tumor stage. Expression of γ-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative. In 2 metastatic cases and in the case of bilateral Wilms' tumor γ-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of γ-catenin and unfavorable outcome.",
journal = "Fetal & Pediatric Pathology",
title = "Immunohistochemical analysis of gamma catenin in Wilms' tumors",
volume = "27",
number = "2",
pages = "63-70",
doi = "10.1080/15513810802028704"
}
Basta-Jovanović, G., Gvozdenović, E., Dimitrijević, I., Brašanac, D., Vučković, M., Kalezić, N., Baralić, I., Radojević-Škodrić, S.,& Arsić, D.. (2008). Immunohistochemical analysis of gamma catenin in Wilms' tumors. in Fetal & Pediatric Pathology, 27(2), 63-70.
https://doi.org/10.1080/15513810802028704
Basta-Jovanović G, Gvozdenović E, Dimitrijević I, Brašanac D, Vučković M, Kalezić N, Baralić I, Radojević-Škodrić S, Arsić D. Immunohistochemical analysis of gamma catenin in Wilms' tumors. in Fetal & Pediatric Pathology. 2008;27(2):63-70.
doi:10.1080/15513810802028704 .
Basta-Jovanović, Gordana, Gvozdenović, E., Dimitrijević, I., Brašanac, Dimitrije, Vučković, Mila, Kalezić, Nevena, Baralić, I., Radojević-Škodrić, Sanja, Arsić, D., "Immunohistochemical analysis of gamma catenin in Wilms' tumors" in Fetal & Pediatric Pathology, 27, no. 2 (2008):63-70,
https://doi.org/10.1080/15513810802028704 . .
