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dc.creatorBasta-Jovanović, Gordana
dc.creatorSuzić, S.
dc.creatorSavin, M.
dc.creatorPetronijević, Nataša
dc.creatorRadonjić, N.
dc.creatorSignuričić, S.
dc.creatorVučković, Mila
dc.creatorRadojević-Škodrić, Sanja
dc.date.accessioned2020-07-02T12:18:44Z
dc.date.available2020-07-02T12:18:44Z
dc.date.issued2008
dc.identifier.issn0567-8315
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1408
dc.description.abstractProliferative disorders including tumors are recognized as diseases of the cell cycle in which the crucial role belongs to the cyclin-dependent kinase family. The aim of this study was to investigate the expression of protein p16 in the normal kidney, and in Wilms tumor by immunohistochemistry to correlate the obtained results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in the lungs and one case of normal renal tissue. Protein p16 was over expressed in 20 cases of Wilms tumor. Expression of p16 was less frequent in stages III/IV/V than in stages I/III, showing no statistically significant correlation (p > 0.05). Intermediate risk groups of Wilms tumor showed more frequent p16 expression in comparison with high risk cases, showing no statistical significance (p > 0.05). Protein p16 expression was detected in all histologic types of Wilms tumor with the highest expression in the predominantly blastemal type (50%). There was a statistically significant difference between p16 expression in this and its expression in other histological types (p lt 0.05). The correlation between p16 expression and the predominantly blastemal histological type was statistically significant and showed that in such cases tumor cells can proliferate even in the presence of p16.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.rightsrestrictedAccess
dc.sourceActa Veterinaria
dc.subjectCell cycleen
dc.subjectImmunohistochemicalen
dc.subjectProtein p16en
dc.subjectSwineen
dc.subjectWilms tumoren
dc.titleImmunohistochemical expression of protein p16 in Wilms' tumoren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБаста-Јовановић, Гордана; Петронијевић, Наташа; Сигнуричић, С.; Вучковић, Мила; Радојевић-Шкодрић, Сања; Савин, М.; Радоњић, Н.; Сузић, С.;
dc.citation.volume58
dc.citation.issue4
dc.citation.spage297
dc.citation.epage306
dc.citation.other58(4): 297-306
dc.citation.rankM23
dc.identifier.wos000260245200001
dc.identifier.doi10.2298/AVB0804297B
dc.identifier.scopus2-s2.0-53649087259
dc.identifier.rcubconv_3855
dc.type.versionpublishedVersion


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