The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) a...nd 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.
TY - JOUR
AU - Brković, Božidar
AU - Gardašević, Milka
AU - Roganović, Jelena
AU - Jović, N.
AU - Todorović, L.
AU - Stojić, Dragica
PY - 2008
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1426
AB - The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.
PB - Churchill Livingstone, Edinburgh
T2 - International Journal of Oral & Maxillofacial Surgery
T1 - Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects
VL - 37
IS - 2
SP - 149
EP - 155
DO - 10.1016/j.ijom.2007.07.019
ER -
@article{
author = "Brković, Božidar and Gardašević, Milka and Roganović, Jelena and Jović, N. and Todorović, L. and Stojić, Dragica",
year = "2008",
abstract = "The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects",
volume = "37",
number = "2",
pages = "149-155",
doi = "10.1016/j.ijom.2007.07.019"
}
Brković, B., Gardašević, M., Roganović, J., Jović, N., Todorović, L.,& Stojić, D.. (2008). Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 37(2), 149-155.
https://doi.org/10.1016/j.ijom.2007.07.019
Brković B, Gardašević M, Roganović J, Jović N, Todorović L, Stojić D. Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. in International Journal of Oral & Maxillofacial Surgery. 2008;37(2):149-155.
doi:10.1016/j.ijom.2007.07.019 .
Brković, Božidar, Gardašević, Milka, Roganović, Jelena, Jović, N., Todorović, L., Stojić, Dragica, "Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects" in International Journal of Oral & Maxillofacial Surgery, 37, no. 2 (2008):149-155,
https://doi.org/10.1016/j.ijom.2007.07.019 . .
