Introduction. The primary goal of bone regeneration procedures with application of various regenerative biologic agents and biomaterials is to facilitate the formation of periodontal tissues lost as a result of periodontitis. Objective. The aim of the study was to compare clinical outcome of the guided tissue regeneration (GTR) treatment with the use of β-tricalcium phosphate and with bovine bone matrix in human deep intra-osseous defects. Methods. Twenty-one systemically healthy subjects with moderate to advanced periodontitis, between 30 and 56 years of age, 11 females and 10 males, were selected. Patients having two similar inter-proximal defects with pocket probing depths following initial therapy greater than 5 mm were recruited for the study. Experimental sites were grafted with pure β-tricalcium phosphate biomaterial (Cerasorb®) and a biomembrane, while control sites were treated with bovine-bone hydroxiapatite xenograft (Bio-oss®) and a biomembrane. Immediately before surgery a...nd 12 months after surgery, pocket probing depth (PPD), epithelial attachment level (EAL) and gingival recession (GR) were evaluated. Results. In the experimental group PPD amounted to 6.76±0.83 mm before surgery, and decreased significantly to 2.67±0.48 mm 12 months following surgery, while in the control group PPD significantly decreased from 7.14±0.65 mm presurgically to 2.85±0.57 mm postsurgically. After one year, EAL gain was 2.76±0.99 mm in the experimental group, and 3.24±0.16 mm in the control group. After twelve months postoperatively GR amounted to 1.33±0.79 mm in the experimental group and to 1.05±0.80 mm in the control group. No statistically significant differences for PPD reduction, EAL gain and GR increase were detected between the groups. Conclusion. Results from the present study indicate that GTR treatment of deep intra-osseous defects with Bio-oss® and Cerasorb® resulted in clinically and statistically significant improvement of EAL gain and PPD reduction. A GR was slightly increased, with no statistical significance.
Uvod. Za regeneraciju tkiva koje je izgubljeno tokom parodontopatije koriste se razni biološki i sintetski materijali s različitim uspehom. Oni se najčešće primenjuju za obnavljanje pripojnog epitela i gubljenje alveolarne kosti u dubokim infrakoštanim oštećenjima. Cilj rada. Cilj rada je bio da se ispita značaj primene beta trikalcijum-fosfata i hidroksiapatita u lečenju dubokih infrakoštanih oštećenja. Metode rada. U istraživanje je uključena dvadeset i jedna zdrava osoba (11 žena i 10 muškaraca) starosti 30-45 godina kod koje je dijagnostikovana parodontopatija. Kod svih ispitanika ustanovljena su dva slična oštećenja sa dubinom sondiranja džepa od preko 5 mm. Tzv. eksperimentalna strana je tretirana čistim beta trikalcijum-fosfatnim biomaterijalom (Cerasorb®) i biomembranom, dok je tzv. kontrolna strana tretirana hidroksiapatitnim goveđim koštanim ksenograftom (Bio-oss®) i biomembranom. Dubina sondiranja džepa, nivo pripojenog epitela i recesija gingive su zabeleženi neposredno pre... intervencije i 12 meseci kasnije. Rezultati. U eksperimentalnoj grupi dubina sondiranja džepa je bila 6,76±0,83 mm pre intervencije, a značajno manja nakon 12 meseci (2,76±0,48 mm). U kontrolnoj grupi ona je bila 7,14±0,65 mm pre intervencije, a značajno manja na kontrolnom pregledu (2,85±0,57 mm). Posle godinu dana nivo pripojenog epitela se povećao 2,76±0,99 mm u eksperimentalnoj grupi, odnosno 3,24±0,16 mm u kontrolnoj. Dvanaest meseci nakon intervencije recesija gingive bila je 1,33±0,79 mm u eksperimentalnoj, odnosno 1,05±0,80 mm u kontrolnoj grupi. Nisu zabeležene statistički značajne razlike u vrednosti dubine sondiranja džepa, nivou pripojenog epitela i recesiji gingive između kontrolne i eksperimentalne grupe. Zaključak. Tretman dubokih infrakoštanih oštećenja beta trikalcijum-fosfatom i hidroksiapatitom dao je dobre kliničke rezultate, budući da se značajno smanjila dubina oštećenja, a nivo pripojenog epitela podigao. Recesija gingive se umanjila, ali bez statistički značajne razlike.
TY - JOUR
AU - Luković, Natalija
AU - Zelić, Obrad
AU - Čakić, Saša
AU - Petrović, Vanja
PY - 2009
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1461
AB - Introduction. The primary goal of bone regeneration procedures with application of various regenerative biologic agents and biomaterials is to facilitate the formation of periodontal tissues lost as a result of periodontitis. Objective. The aim of the study was to compare clinical outcome of the guided tissue regeneration (GTR) treatment with the use of β-tricalcium phosphate and with bovine bone matrix in human deep intra-osseous defects. Methods. Twenty-one systemically healthy subjects with moderate to advanced periodontitis, between 30 and 56 years of age, 11 females and 10 males, were selected. Patients having two similar inter-proximal defects with pocket probing depths following initial therapy greater than 5 mm were recruited for the study. Experimental sites were grafted with pure β-tricalcium phosphate biomaterial (Cerasorb®) and a biomembrane, while control sites were treated with bovine-bone hydroxiapatite xenograft (Bio-oss®) and a biomembrane. Immediately before surgery and 12 months after surgery, pocket probing depth (PPD), epithelial attachment level (EAL) and gingival recession (GR) were evaluated. Results. In the experimental group PPD amounted to 6.76±0.83 mm before surgery, and decreased significantly to 2.67±0.48 mm 12 months following surgery, while in the control group PPD significantly decreased from 7.14±0.65 mm presurgically to 2.85±0.57 mm postsurgically. After one year, EAL gain was 2.76±0.99 mm in the experimental group, and 3.24±0.16 mm in the control group. After twelve months postoperatively GR amounted to 1.33±0.79 mm in the experimental group and to 1.05±0.80 mm in the control group. No statistically significant differences for PPD reduction, EAL gain and GR increase were detected between the groups. Conclusion. Results from the present study indicate that GTR treatment of deep intra-osseous defects with Bio-oss® and Cerasorb® resulted in clinically and statistically significant improvement of EAL gain and PPD reduction. A GR was slightly increased, with no statistical significance.
AB - Uvod. Za regeneraciju tkiva koje je izgubljeno tokom parodontopatije koriste se razni biološki i sintetski materijali s različitim uspehom. Oni se najčešće primenjuju za obnavljanje pripojnog epitela i gubljenje alveolarne kosti u dubokim infrakoštanim oštećenjima. Cilj rada. Cilj rada je bio da se ispita značaj primene beta trikalcijum-fosfata i hidroksiapatita u lečenju dubokih infrakoštanih oštećenja. Metode rada. U istraživanje je uključena dvadeset i jedna zdrava osoba (11 žena i 10 muškaraca) starosti 30-45 godina kod koje je dijagnostikovana parodontopatija. Kod svih ispitanika ustanovljena su dva slična oštećenja sa dubinom sondiranja džepa od preko 5 mm. Tzv. eksperimentalna strana je tretirana čistim beta trikalcijum-fosfatnim biomaterijalom (Cerasorb®) i biomembranom, dok je tzv. kontrolna strana tretirana hidroksiapatitnim goveđim koštanim ksenograftom (Bio-oss®) i biomembranom. Dubina sondiranja džepa, nivo pripojenog epitela i recesija gingive su zabeleženi neposredno pre intervencije i 12 meseci kasnije. Rezultati. U eksperimentalnoj grupi dubina sondiranja džepa je bila 6,76±0,83 mm pre intervencije, a značajno manja nakon 12 meseci (2,76±0,48 mm). U kontrolnoj grupi ona je bila 7,14±0,65 mm pre intervencije, a značajno manja na kontrolnom pregledu (2,85±0,57 mm). Posle godinu dana nivo pripojenog epitela se povećao 2,76±0,99 mm u eksperimentalnoj grupi, odnosno 3,24±0,16 mm u kontrolnoj. Dvanaest meseci nakon intervencije recesija gingive bila je 1,33±0,79 mm u eksperimentalnoj, odnosno 1,05±0,80 mm u kontrolnoj grupi. Nisu zabeležene statistički značajne razlike u vrednosti dubine sondiranja džepa, nivou pripojenog epitela i recesiji gingive između kontrolne i eksperimentalne grupe. Zaključak. Tretman dubokih infrakoštanih oštećenja beta trikalcijum-fosfatom i hidroksiapatitom dao je dobre kliničke rezultate, budući da se značajno smanjila dubina oštećenja, a nivo pripojenog epitela podigao. Recesija gingive se umanjila, ali bez statistički značajne razlike.
PB - Srpsko lekarsko društvo, Beograd
T2 - Srpski arhiv za celokupno lekarstvo
T1 - The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects
T1 - Primena beta trikalcijum-fosfata i goveđeg koštanog matriksa u vođenoj regeneraciji dubokih infrakoštanih parodontalnih oštećenja
VL - 137
IS - 11-12
SP - 607
EP - 612
DO - 10.2298/SARH0912607L
ER -
@article{
author = "Luković, Natalija and Zelić, Obrad and Čakić, Saša and Petrović, Vanja",
year = "2009",
abstract = "Introduction. The primary goal of bone regeneration procedures with application of various regenerative biologic agents and biomaterials is to facilitate the formation of periodontal tissues lost as a result of periodontitis. Objective. The aim of the study was to compare clinical outcome of the guided tissue regeneration (GTR) treatment with the use of β-tricalcium phosphate and with bovine bone matrix in human deep intra-osseous defects. Methods. Twenty-one systemically healthy subjects with moderate to advanced periodontitis, between 30 and 56 years of age, 11 females and 10 males, were selected. Patients having two similar inter-proximal defects with pocket probing depths following initial therapy greater than 5 mm were recruited for the study. Experimental sites were grafted with pure β-tricalcium phosphate biomaterial (Cerasorb®) and a biomembrane, while control sites were treated with bovine-bone hydroxiapatite xenograft (Bio-oss®) and a biomembrane. Immediately before surgery and 12 months after surgery, pocket probing depth (PPD), epithelial attachment level (EAL) and gingival recession (GR) were evaluated. Results. In the experimental group PPD amounted to 6.76±0.83 mm before surgery, and decreased significantly to 2.67±0.48 mm 12 months following surgery, while in the control group PPD significantly decreased from 7.14±0.65 mm presurgically to 2.85±0.57 mm postsurgically. After one year, EAL gain was 2.76±0.99 mm in the experimental group, and 3.24±0.16 mm in the control group. After twelve months postoperatively GR amounted to 1.33±0.79 mm in the experimental group and to 1.05±0.80 mm in the control group. No statistically significant differences for PPD reduction, EAL gain and GR increase were detected between the groups. Conclusion. Results from the present study indicate that GTR treatment of deep intra-osseous defects with Bio-oss® and Cerasorb® resulted in clinically and statistically significant improvement of EAL gain and PPD reduction. A GR was slightly increased, with no statistical significance., Uvod. Za regeneraciju tkiva koje je izgubljeno tokom parodontopatije koriste se razni biološki i sintetski materijali s različitim uspehom. Oni se najčešće primenjuju za obnavljanje pripojnog epitela i gubljenje alveolarne kosti u dubokim infrakoštanim oštećenjima. Cilj rada. Cilj rada je bio da se ispita značaj primene beta trikalcijum-fosfata i hidroksiapatita u lečenju dubokih infrakoštanih oštećenja. Metode rada. U istraživanje je uključena dvadeset i jedna zdrava osoba (11 žena i 10 muškaraca) starosti 30-45 godina kod koje je dijagnostikovana parodontopatija. Kod svih ispitanika ustanovljena su dva slična oštećenja sa dubinom sondiranja džepa od preko 5 mm. Tzv. eksperimentalna strana je tretirana čistim beta trikalcijum-fosfatnim biomaterijalom (Cerasorb®) i biomembranom, dok je tzv. kontrolna strana tretirana hidroksiapatitnim goveđim koštanim ksenograftom (Bio-oss®) i biomembranom. Dubina sondiranja džepa, nivo pripojenog epitela i recesija gingive su zabeleženi neposredno pre intervencije i 12 meseci kasnije. Rezultati. U eksperimentalnoj grupi dubina sondiranja džepa je bila 6,76±0,83 mm pre intervencije, a značajno manja nakon 12 meseci (2,76±0,48 mm). U kontrolnoj grupi ona je bila 7,14±0,65 mm pre intervencije, a značajno manja na kontrolnom pregledu (2,85±0,57 mm). Posle godinu dana nivo pripojenog epitela se povećao 2,76±0,99 mm u eksperimentalnoj grupi, odnosno 3,24±0,16 mm u kontrolnoj. Dvanaest meseci nakon intervencije recesija gingive bila je 1,33±0,79 mm u eksperimentalnoj, odnosno 1,05±0,80 mm u kontrolnoj grupi. Nisu zabeležene statistički značajne razlike u vrednosti dubine sondiranja džepa, nivou pripojenog epitela i recesiji gingive između kontrolne i eksperimentalne grupe. Zaključak. Tretman dubokih infrakoštanih oštećenja beta trikalcijum-fosfatom i hidroksiapatitom dao je dobre kliničke rezultate, budući da se značajno smanjila dubina oštećenja, a nivo pripojenog epitela podigao. Recesija gingive se umanjila, ali bez statistički značajne razlike.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects, Primena beta trikalcijum-fosfata i goveđeg koštanog matriksa u vođenoj regeneraciji dubokih infrakoštanih parodontalnih oštećenja",
volume = "137",
number = "11-12",
pages = "607-612",
doi = "10.2298/SARH0912607L"
}
Luković, N., Zelić, O., Čakić, S.,& Petrović, V.. (2009). The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 137(11-12), 607-612.
https://doi.org/10.2298/SARH0912607L
Luković N, Zelić O, Čakić S, Petrović V. The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects. in Srpski arhiv za celokupno lekarstvo. 2009;137(11-12):607-612.
doi:10.2298/SARH0912607L .
Luković, Natalija, Zelić, Obrad, Čakić, Saša, Petrović, Vanja, "The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects" in Srpski arhiv za celokupno lekarstvo, 137, no. 11-12 (2009):607-612,
https://doi.org/10.2298/SARH0912607L . .
