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dc.creatorHadži-Mihailović, Miloš
dc.creatorRaybaud, Helene
dc.creatorMonteil, R.
dc.creatorJanković, Ljiljana
dc.date.accessioned2020-07-02T12:24:11Z
dc.date.available2020-07-02T12:24:11Z
dc.date.issued2009
dc.identifier.issn1107-0625
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1491
dc.description.abstractPurpose: To investigate the malignant potential of oral lichen planus (OLP) on the basis of expression of the Fas/FasL markers in healthy individuals (H), OLP patients and patients with squamous cell carcinoma (SCC). Patients and methods: 40 patients with OLP and two control groups were included in this research (H and patients with SCC). Immunohislochemistry for Fas and FasL was carried out using an avidin-biotin peroxidase complex method. Results: Only a low percentage of infiltrating lymphocytes and no keratinocytes were Fas-positive in OLP specimens. The highest percentage of Fas-staining keratinocytes in our survey was identified mostly in H and patients with well-differentiated SCC In most cases of SCC, OLP and H a high percentage of keratinocytes and lymphocytes were FasL-positive. FasL expression was negatively correlated with the degree of cell differentiation and apoptosis. Taking into consideration that all carcinomas in this survey were highly differentiated, it is not surprising that no statistically significant differences in FasL expression between H, OLP and SCC specimens were detected Conclusion: Downregulation of Fas expression in keratinocytes and lymphocytes of OLP specimens, together with upregulation of FasL, may serve as initial prognostic biomarker in oral cancer development.en
dc.publisherBalkan Union of Oncology (B.U.ON.)
dc.relationLaboratory of Oral Pathology, Hospital "Pasteur", Nice, France
dc.rightsrestrictedAccess
dc.sourceJournal of BUON
dc.subjectFasen
dc.subjectFasLen
dc.subjectoral lichen planusen
dc.subjectpremalignant lesionsen
dc.titleExpression of Fas/FasL in patients with oral lichen planusen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractХаджи-Михаиловић, Милош; Раyбауд, Хелене; Монтеил, Р.; Јанковић, Љиљана;
dc.citation.volume14
dc.citation.issue3
dc.citation.spage487
dc.citation.epage493
dc.citation.other14(3): 487-493
dc.citation.rankM23
dc.identifier.wos000270421300019
dc.identifier.pmid19810143
dc.identifier.rcubconv_2848
dc.type.versionpublishedVersion


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