The main purpose of this Study was to assess the clinical efficacy and haemodynamic effects of ropivacaine for infiltration anaesthesia in patients undergoing surgical removal of upper third molars. The safety profile of ropivacaine was also Studied by investigating the maximal venous plasma concentration of ropivacaine and the reactivity to ropivacaine of isolated human infraorbital arteries. Ropivacaine in concentrations of 0.5, 0.75 and 1% achieved dose-dependent parameters of maxillary infiltration aneasthesia, clinically relevant in concentrations 0.75 and 1%. Postoperative needs for analgesics were observed in 67-100% of patients. Haemodynamic parameters were stable during surgery with significant changes occuring 10 min after surgery. After maxillary infiltration of 2.0 ml 1% ropivacaine, the maximum venous plasma concentration Cmax) was 82 +/- 15 mg/l. On isolated human infraorbital artery, ropivacaine (10(-4) M) induced endothelium-independent contraction. This study suggests ...that 0.75 and 1% ropivacaine offers adequate and safe intraoperative analgesia but not Successful postoperative pain control for the surgical removal Of upper third molars.
TY - JOUR
AU - Brković, Božidar
AU - Zlatković, M.
AU - Jovanović, D.
AU - Stojić, Dragica
PY - 2010
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1530
AB - The main purpose of this Study was to assess the clinical efficacy and haemodynamic effects of ropivacaine for infiltration anaesthesia in patients undergoing surgical removal of upper third molars. The safety profile of ropivacaine was also Studied by investigating the maximal venous plasma concentration of ropivacaine and the reactivity to ropivacaine of isolated human infraorbital arteries. Ropivacaine in concentrations of 0.5, 0.75 and 1% achieved dose-dependent parameters of maxillary infiltration aneasthesia, clinically relevant in concentrations 0.75 and 1%. Postoperative needs for analgesics were observed in 67-100% of patients. Haemodynamic parameters were stable during surgery with significant changes occuring 10 min after surgery. After maxillary infiltration of 2.0 ml 1% ropivacaine, the maximum venous plasma concentration Cmax) was 82 +/- 15 mg/l. On isolated human infraorbital artery, ropivacaine (10(-4) M) induced endothelium-independent contraction. This study suggests that 0.75 and 1% ropivacaine offers adequate and safe intraoperative analgesia but not Successful postoperative pain control for the surgical removal Of upper third molars.
PB - Churchill Livingstone, Edinburgh
T2 - International Journal of Oral & Maxillofacial Surgery
T1 - Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery
VL - 39
IS - 1
SP - 36
EP - 41
DO - 10.1016/j.ijom.2009.11.009
ER -
@article{
author = "Brković, Božidar and Zlatković, M. and Jovanović, D. and Stojić, Dragica",
year = "2010",
abstract = "The main purpose of this Study was to assess the clinical efficacy and haemodynamic effects of ropivacaine for infiltration anaesthesia in patients undergoing surgical removal of upper third molars. The safety profile of ropivacaine was also Studied by investigating the maximal venous plasma concentration of ropivacaine and the reactivity to ropivacaine of isolated human infraorbital arteries. Ropivacaine in concentrations of 0.5, 0.75 and 1% achieved dose-dependent parameters of maxillary infiltration aneasthesia, clinically relevant in concentrations 0.75 and 1%. Postoperative needs for analgesics were observed in 67-100% of patients. Haemodynamic parameters were stable during surgery with significant changes occuring 10 min after surgery. After maxillary infiltration of 2.0 ml 1% ropivacaine, the maximum venous plasma concentration Cmax) was 82 +/- 15 mg/l. On isolated human infraorbital artery, ropivacaine (10(-4) M) induced endothelium-independent contraction. This study suggests that 0.75 and 1% ropivacaine offers adequate and safe intraoperative analgesia but not Successful postoperative pain control for the surgical removal Of upper third molars.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery",
volume = "39",
number = "1",
pages = "36-41",
doi = "10.1016/j.ijom.2009.11.009"
}
Brković, B., Zlatković, M., Jovanović, D.,& Stojić, D.. (2010). Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 39(1), 36-41.
https://doi.org/10.1016/j.ijom.2009.11.009
Brković B, Zlatković M, Jovanović D, Stojić D. Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery. in International Journal of Oral & Maxillofacial Surgery. 2010;39(1):36-41.
doi:10.1016/j.ijom.2009.11.009 .
Brković, Božidar, Zlatković, M., Jovanović, D., Stojić, Dragica, "Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery" in International Journal of Oral & Maxillofacial Surgery, 39, no. 1 (2010):36-41,
https://doi.org/10.1016/j.ijom.2009.11.009 . .
