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dc.creatorBrković, Božidar
dc.creatorZlatković, M.
dc.creatorJovanović, D.
dc.creatorStojić, Dragica
dc.date.accessioned2020-07-02T12:26:46Z
dc.date.available2020-07-02T12:26:46Z
dc.date.issued2010
dc.identifier.issn0901-5027
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1530
dc.description.abstractThe main purpose of this Study was to assess the clinical efficacy and haemodynamic effects of ropivacaine for infiltration anaesthesia in patients undergoing surgical removal of upper third molars. The safety profile of ropivacaine was also Studied by investigating the maximal venous plasma concentration of ropivacaine and the reactivity to ropivacaine of isolated human infraorbital arteries. Ropivacaine in concentrations of 0.5, 0.75 and 1% achieved dose-dependent parameters of maxillary infiltration aneasthesia, clinically relevant in concentrations 0.75 and 1%. Postoperative needs for analgesics were observed in 67-100% of patients. Haemodynamic parameters were stable during surgery with significant changes occuring 10 min after surgery. After maxillary infiltration of 2.0 ml 1% ropivacaine, the maximum venous plasma concentration Cmax) was 82 +/- 15 mg/l. On isolated human infraorbital artery, ropivacaine (10(-4) M) induced endothelium-independent contraction. This study suggests that 0.75 and 1% ropivacaine offers adequate and safe intraoperative analgesia but not Successful postoperative pain control for the surgical removal Of upper third molars.en
dc.publisherChurchill Livingstone, Edinburgh
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Oral & Maxillofacial Surgery
dc.subjectropivacaineen
dc.subjectmaxillary infiltration anaesthesiaen
dc.subjectcardiovascular parametersen
dc.subjectropivacaine-induced vasoconstrictionen
dc.subjectC-max and t(max)en
dc.titleMaxillary infiltration anaesthesia by ropivacaine for upper third molar surgeryen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојић, Драгица; Златковић, М.; Јовановић, Д.; Брковић, Божидар;
dc.citation.volume39
dc.citation.issue1
dc.citation.spage36
dc.citation.epage41
dc.citation.other39(1): 36-41
dc.citation.rankM22
dc.identifier.wos000274842400007
dc.identifier.doi10.1016/j.ijom.2009.11.009
dc.identifier.pmid20005673
dc.identifier.scopus2-s2.0-74249083189
dc.type.versionpublishedVersion


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