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Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection

Authorized Users Only
2010
Authors
Andrić, Miroslav
Dožić, Branko
Popović, Branka
Stefanović, D.
Basta-Jovanović, Gordana
Đogo, N.
Andjus, P.
Milašin, Jelena
Article (Published version)
Metadata
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Abstract
Objectives: The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts. Materials and methods: Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin. Results: All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression ...of survivin within odontogenic keratocysts. Conclusion: Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature.

Keywords:
survivin expression / odontogenic keratocyst / keratocystic odontogenic tumor / cytomegalovirus / periapical cyst
Source:
Oral Diseases, 2010, 16, 2, 156-159
Publisher:
  • Wiley, Hoboken
Funding / projects:
  • School of Dentistry, University of Belgrade
  • Biofizičko neuroprofiliranje na eksperimentalnim modelima oštećenja i oporavka centralnog nervnog sistema (RS-143054)

DOI: 10.1111/j.1601-0825.2009.01612.x

ISSN: 1354-523X

PubMed: 19659890

WoS: 000274713400006

Scopus: 2-s2.0-77249173888
[ Google Scholar ]
14
11
URI
https://smile.stomf.bg.ac.rs/handle/123456789/1531
Collections
  • Radovi istraživača
Institution/Community
Stomatološki fakultet
TY  - JOUR
AU  - Andrić, Miroslav
AU  - Dožić, Branko
AU  - Popović, Branka
AU  - Stefanović, D.
AU  - Basta-Jovanović, Gordana
AU  - Đogo, N.
AU  - Andjus, P.
AU  - Milašin, Jelena
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1531
AB  - Objectives: The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts. Materials and methods: Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin. Results: All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression of survivin within odontogenic keratocysts. Conclusion: Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection
VL  - 16
IS  - 2
SP  - 156
EP  - 159
DO  - 10.1111/j.1601-0825.2009.01612.x
ER  - 
@article{
author = "Andrić, Miroslav and Dožić, Branko and Popović, Branka and Stefanović, D. and Basta-Jovanović, Gordana and Đogo, N. and Andjus, P. and Milašin, Jelena",
year = "2010",
abstract = "Objectives: The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts. Materials and methods: Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin. Results: All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression of survivin within odontogenic keratocysts. Conclusion: Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection",
volume = "16",
number = "2",
pages = "156-159",
doi = "10.1111/j.1601-0825.2009.01612.x"
}
Andrić, M., Dožić, B., Popović, B., Stefanović, D., Basta-Jovanović, G., Đogo, N., Andjus, P.,& Milašin, J.. (2010). Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection. in Oral Diseases
Wiley, Hoboken., 16(2), 156-159.
https://doi.org/10.1111/j.1601-0825.2009.01612.x
Andrić M, Dožić B, Popović B, Stefanović D, Basta-Jovanović G, Đogo N, Andjus P, Milašin J. Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection. in Oral Diseases. 2010;16(2):156-159.
doi:10.1111/j.1601-0825.2009.01612.x .
Andrić, Miroslav, Dožić, Branko, Popović, Branka, Stefanović, D., Basta-Jovanović, Gordana, Đogo, N., Andjus, P., Milašin, Jelena, "Survivin expression in odontogenic keratocysts and correlation with cytomegalovirus infection" in Oral Diseases, 16, no. 2 (2010):156-159,
https://doi.org/10.1111/j.1601-0825.2009.01612.x . .

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