Cancer genes alterations and HPV infection in oral squamous cell carcinoma
Само за регистроване кориснике
2010
Аутори
Popović, Branka
Jekić, Biljana

Novaković, Ivana

Luković, Ljiljana
Konstantinović, Vitomir

Babić, Marko
Milašin, Jelena

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to gain a better understanding of cancer genes contributing to oral squamous cell (OSCC) development and progression and correlate genetic changes to clinical parameters. Human papilloma virus (HPV) 16 detection is also included in the study. 60 samples of OSCC were analysed for erbB2 and c-myc amplification by dPCR, H-ras and p53 point mutations by PCR/SSCP. HPV was detected via amplification of its El and E6 genes. c-erbB2 was altered in 45%, c-myc in 35%, H-ras in 22% and p53 in 60% of samples. HPV was detected in 10% of cases. The frequency of p53 gene mutations showed a statistically significant association with tumour stage. Patients with c-erbB2 and H-ras alterations had lower survival than patients without these alterations. The number of detected genetic changes was remarkable but statistical association with tumour natural history was poor, indicating high clonal heterogeneity and multiple pathways of carcinogenesis.
Кључне речи:
cancer / genes / oral squamous cell carcinoma / HPVИзвор:
International Journal of Oral & Maxillofacial Surgery, 2010, 39, 9, 909-915Издавач:
- Churchill Livingstone, Edinburgh
Финансирање / пројекти:
- Парадонтална медицина, примена концепта активне регенерације у парадонтологији и имплантологији (RS-145042)
DOI: 10.1016/j.ijom.2010.05.007
ISSN: 0901-5027
PubMed: 20579853
WoS: 000283761500013
Scopus: 2-s2.0-77957268782
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Popović, Branka AU - Jekić, Biljana AU - Novaković, Ivana AU - Luković, Ljiljana AU - Konstantinović, Vitomir AU - Babić, Marko AU - Milašin, Jelena PY - 2010 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1564 AB - The aim of this study was to gain a better understanding of cancer genes contributing to oral squamous cell (OSCC) development and progression and correlate genetic changes to clinical parameters. Human papilloma virus (HPV) 16 detection is also included in the study. 60 samples of OSCC were analysed for erbB2 and c-myc amplification by dPCR, H-ras and p53 point mutations by PCR/SSCP. HPV was detected via amplification of its El and E6 genes. c-erbB2 was altered in 45%, c-myc in 35%, H-ras in 22% and p53 in 60% of samples. HPV was detected in 10% of cases. The frequency of p53 gene mutations showed a statistically significant association with tumour stage. Patients with c-erbB2 and H-ras alterations had lower survival than patients without these alterations. The number of detected genetic changes was remarkable but statistical association with tumour natural history was poor, indicating high clonal heterogeneity and multiple pathways of carcinogenesis. PB - Churchill Livingstone, Edinburgh T2 - International Journal of Oral & Maxillofacial Surgery T1 - Cancer genes alterations and HPV infection in oral squamous cell carcinoma VL - 39 IS - 9 SP - 909 EP - 915 DO - 10.1016/j.ijom.2010.05.007 ER -
@article{ author = "Popović, Branka and Jekić, Biljana and Novaković, Ivana and Luković, Ljiljana and Konstantinović, Vitomir and Babić, Marko and Milašin, Jelena", year = "2010", abstract = "The aim of this study was to gain a better understanding of cancer genes contributing to oral squamous cell (OSCC) development and progression and correlate genetic changes to clinical parameters. Human papilloma virus (HPV) 16 detection is also included in the study. 60 samples of OSCC were analysed for erbB2 and c-myc amplification by dPCR, H-ras and p53 point mutations by PCR/SSCP. HPV was detected via amplification of its El and E6 genes. c-erbB2 was altered in 45%, c-myc in 35%, H-ras in 22% and p53 in 60% of samples. HPV was detected in 10% of cases. The frequency of p53 gene mutations showed a statistically significant association with tumour stage. Patients with c-erbB2 and H-ras alterations had lower survival than patients without these alterations. The number of detected genetic changes was remarkable but statistical association with tumour natural history was poor, indicating high clonal heterogeneity and multiple pathways of carcinogenesis.", publisher = "Churchill Livingstone, Edinburgh", journal = "International Journal of Oral & Maxillofacial Surgery", title = "Cancer genes alterations and HPV infection in oral squamous cell carcinoma", volume = "39", number = "9", pages = "909-915", doi = "10.1016/j.ijom.2010.05.007" }
Popović, B., Jekić, B., Novaković, I., Luković, L., Konstantinović, V., Babić, M.,& Milašin, J.. (2010). Cancer genes alterations and HPV infection in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery Churchill Livingstone, Edinburgh., 39(9), 909-915. https://doi.org/10.1016/j.ijom.2010.05.007
Popović B, Jekić B, Novaković I, Luković L, Konstantinović V, Babić M, Milašin J. Cancer genes alterations and HPV infection in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery. 2010;39(9):909-915. doi:10.1016/j.ijom.2010.05.007 .
Popović, Branka, Jekić, Biljana, Novaković, Ivana, Luković, Ljiljana, Konstantinović, Vitomir, Babić, Marko, Milašin, Jelena, "Cancer genes alterations and HPV infection in oral squamous cell carcinoma" in International Journal of Oral & Maxillofacial Surgery, 39, no. 9 (2010):909-915, https://doi.org/10.1016/j.ijom.2010.05.007 . .