Приказ основних података о документу

dc.creatorPopović, Branka
dc.creatorJekić, Biljana
dc.creatorNovaković, Ivana
dc.creatorLuković, Ljiljana
dc.creatorKonstantinović, Vitomir
dc.creatorBabić, Marko
dc.creatorMilašin, Jelena
dc.date.accessioned2020-07-02T12:28:59Z
dc.date.available2020-07-02T12:28:59Z
dc.date.issued2010
dc.identifier.issn0901-5027
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1564
dc.description.abstractThe aim of this study was to gain a better understanding of cancer genes contributing to oral squamous cell (OSCC) development and progression and correlate genetic changes to clinical parameters. Human papilloma virus (HPV) 16 detection is also included in the study. 60 samples of OSCC were analysed for erbB2 and c-myc amplification by dPCR, H-ras and p53 point mutations by PCR/SSCP. HPV was detected via amplification of its El and E6 genes. c-erbB2 was altered in 45%, c-myc in 35%, H-ras in 22% and p53 in 60% of samples. HPV was detected in 10% of cases. The frequency of p53 gene mutations showed a statistically significant association with tumour stage. Patients with c-erbB2 and H-ras alterations had lower survival than patients without these alterations. The number of detected genetic changes was remarkable but statistical association with tumour natural history was poor, indicating high clonal heterogeneity and multiple pathways of carcinogenesis.en
dc.publisherChurchill Livingstone, Edinburgh
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145042/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Oral & Maxillofacial Surgery
dc.subjectcanceren
dc.subjectgenesen
dc.subjectoral squamous cell carcinomaen
dc.subjectHPVen
dc.titleCancer genes alterations and HPV infection in oral squamous cell carcinomaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКонстантиновић, Витомир; Луковић, Љиљана; Бабић, Марко; Милашин, Јелена; Поповић, Бранка; Јекић, Биљана; Новаковић, Ивана;
dc.citation.volume39
dc.citation.issue9
dc.citation.spage909
dc.citation.epage915
dc.citation.other39(9): 909-915
dc.citation.rankM22
dc.identifier.wos000283761500013
dc.identifier.doi10.1016/j.ijom.2010.05.007
dc.identifier.pmid20579853
dc.identifier.scopus2-s2.0-77957268782
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу