Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C > T and 1298A > C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.
TY - JOUR
AU - Damnjanović, Tatjana
AU - Milicević, Radomir
AU - Novković, Tanja
AU - Jovičić, Olivera
AU - Bunjevački, Vera
AU - Jekić, Biljana
AU - Luković, Ljiljana
AU - Novaković, Ivana
AU - Redzić, Danka
AU - Milašin, Jelena
PY - 2010
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1582
AB - Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C > T and 1298A > C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.
PB - Lippincott Williams & Wilkins, Philadelphia
T2 - Journal of Pediatric Hematology Oncology
T1 - Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children
VL - 32
IS - 4
SP - E148
EP - E150
DO - 10.1097/MPH.0b013e3181cbd252
ER -
@article{
author = "Damnjanović, Tatjana and Milicević, Radomir and Novković, Tanja and Jovičić, Olivera and Bunjevački, Vera and Jekić, Biljana and Luković, Ljiljana and Novaković, Ivana and Redzić, Danka and Milašin, Jelena",
year = "2010",
abstract = "Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C > T and 1298A > C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Pediatric Hematology Oncology",
title = "Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children",
volume = "32",
number = "4",
pages = "E148-E150",
doi = "10.1097/MPH.0b013e3181cbd252"
}
Damnjanović, T., Milicević, R., Novković, T., Jovičić, O., Bunjevački, V., Jekić, B., Luković, L., Novaković, I., Redzić, D.,& Milašin, J.. (2010). Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children. in Journal of Pediatric Hematology Oncology
Lippincott Williams & Wilkins, Philadelphia., 32(4), E148-E150.
https://doi.org/10.1097/MPH.0b013e3181cbd252
Damnjanović T, Milicević R, Novković T, Jovičić O, Bunjevački V, Jekić B, Luković L, Novaković I, Redzić D, Milašin J. Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children. in Journal of Pediatric Hematology Oncology. 2010;32(4):E148-E150.
doi:10.1097/MPH.0b013e3181cbd252 .
Damnjanović, Tatjana, Milicević, Radomir, Novković, Tanja, Jovičić, Olivera, Bunjevački, Vera, Jekić, Biljana, Luković, Ljiljana, Novaković, Ivana, Redzić, Danka, Milašin, Jelena, "Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children" in Journal of Pediatric Hematology Oncology, 32, no. 4 (2010):E148-E150,
https://doi.org/10.1097/MPH.0b013e3181cbd252 . .
