Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children
Samo za registrovane korisnike
2010
Autori
Damnjanović, TatjanaMilicević, Radomir
Novković, Tanja
Jovičić, Olivera
Bunjevački, Vera
Jekić, Biljana
Luković, Ljiljana
Novaković, Ivana
Redzić, Danka
Milašin, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C > T and 1298A > C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.
Ključne reči:
MTHFR polymorphisms / acute lymphoblastic leukemia / risk factorIzvor:
Journal of Pediatric Hematology Oncology, 2010, 32, 4, E148-E150Izdavač:
- Lippincott Williams & Wilkins, Philadelphia
Finansiranje / projekti:
- Uticaj genetske varijabilnosti folatnog ciklusa na predispoziciju ka oboljenjima i modulaciji terapeutskog odgovora (RS-MESTD-MPN2006-2010-145075)
DOI: 10.1097/MPH.0b013e3181cbd252
ISSN: 1077-4114
PubMed: 20445408
WoS: 000277920400033
Scopus: 2-s2.0-77952749179
Kolekcije
Institucija/grupa
Stomatološki fakultetTY - JOUR AU - Damnjanović, Tatjana AU - Milicević, Radomir AU - Novković, Tanja AU - Jovičić, Olivera AU - Bunjevački, Vera AU - Jekić, Biljana AU - Luković, Ljiljana AU - Novaković, Ivana AU - Redzić, Danka AU - Milašin, Jelena PY - 2010 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1582 AB - Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C > T and 1298A > C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls. PB - Lippincott Williams & Wilkins, Philadelphia T2 - Journal of Pediatric Hematology Oncology T1 - Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children VL - 32 IS - 4 SP - E148 EP - E150 DO - 10.1097/MPH.0b013e3181cbd252 ER -
@article{ author = "Damnjanović, Tatjana and Milicević, Radomir and Novković, Tanja and Jovičić, Olivera and Bunjevački, Vera and Jekić, Biljana and Luković, Ljiljana and Novaković, Ivana and Redzić, Danka and Milašin, Jelena", year = "2010", abstract = "Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C > T and 1298A > C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Journal of Pediatric Hematology Oncology", title = "Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children", volume = "32", number = "4", pages = "E148-E150", doi = "10.1097/MPH.0b013e3181cbd252" }
Damnjanović, T., Milicević, R., Novković, T., Jovičić, O., Bunjevački, V., Jekić, B., Luković, L., Novaković, I., Redzić, D.,& Milašin, J.. (2010). Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children. in Journal of Pediatric Hematology Oncology Lippincott Williams & Wilkins, Philadelphia., 32(4), E148-E150. https://doi.org/10.1097/MPH.0b013e3181cbd252
Damnjanović T, Milicević R, Novković T, Jovičić O, Bunjevački V, Jekić B, Luković L, Novaković I, Redzić D, Milašin J. Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children. in Journal of Pediatric Hematology Oncology. 2010;32(4):E148-E150. doi:10.1097/MPH.0b013e3181cbd252 .
Damnjanović, Tatjana, Milicević, Radomir, Novković, Tanja, Jovičić, Olivera, Bunjevački, Vera, Jekić, Biljana, Luković, Ljiljana, Novaković, Ivana, Redzić, Danka, Milašin, Jelena, "Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children" in Journal of Pediatric Hematology Oncology, 32, no. 4 (2010):E148-E150, https://doi.org/10.1097/MPH.0b013e3181cbd252 . .