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dc.creatorHadži-Mihailović, Miloš
dc.creatorRaybaud, Helene
dc.creatorMontei, R.
dc.creatorČakić, Saša
dc.creatorĐurić, M.
dc.creatorJanković, Ljiljana
dc.date.accessioned2020-07-02T12:30:47Z
dc.date.available2020-07-02T12:30:47Z
dc.date.issued2010
dc.identifier.issn1107-0625
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1591
dc.description.abstractPurpose: The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of the expression of the Bcl-2 marker in healthy individuals (H), patients with OLP and patients with squamous cell carcinoma (SCC), and to establish potential interdependence between expression of Bcl-2 and the different clinical and histopathological parameters in H, OLP, and SCC. Methods: Immunohistochemistry for Bcl-2 was carried out using an avidin-biotin peroxidase complex method. Tissue sections were treated with mouse monoclonal antibody against Bcl-2 (124, DAKO A/S, Denmark; dilution 1/100). Immunohistochemical parameters measured included total tissue area, total stained area and intensity of stain. Results: Keratinocytes were not Bcl-2 positive in H and were sparsely positive in OLP. The number of lymphocytes stained with Bcl-2 was significantly lower in Has compared to patients with SCC and OLP. Bcl-2 staining was weak to moderate in OLP, and moderate to intense in SCC. Bcl-2-positive lymphocytes were more expressed in older OLP patients (>55 years), and in OLP specimens with orthokeratinized epithelium, less developed acanthosis and highest grade of lymphocyte expression. Conclusion: Bcl-2 may not serve as a prognostic biomarker in oral cancer development from OLP, but it could help in selecting patients with higher need of follow up to prevent malignancy.en
dc.publisherBalkan Union of Oncology (B.U.ON.)
dc.relationThe Laboratory of Oral Pathology, "Pasteur" Hospital, Nice, France
dc.rightsrestrictedAccess
dc.sourceJournal of BUON
dc.subjectBcl-2en
dc.subjectoral lichen planusen
dc.subjectpremalignant lesionen
dc.subjectsquamous cell carcinomaen
dc.titleBcl-2 expression and its possible influence on malignant transformation of oral lichen planusen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЧакић, Саша; Ђурић, М.; Јанковић, Љиљана; Хаджи-Михаиловић, Милош; Раyбауд, Хелене; Монтеи, Р.;
dc.citation.volume15
dc.citation.issue2
dc.citation.spage362
dc.citation.epage368
dc.citation.other15(2): 362-368
dc.citation.rankM23
dc.identifier.wos000279655900025
dc.identifier.pmid20658736
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_smile_1591
dc.type.versionpublishedVersion


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