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Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus
dc.creator | Hadži-Mihailović, Miloš | |
dc.creator | Raybaud, Helene | |
dc.creator | Montei, R. | |
dc.creator | Čakić, Saša | |
dc.creator | Đurić, M. | |
dc.creator | Janković, Ljiljana | |
dc.date.accessioned | 2020-07-02T12:30:47Z | |
dc.date.available | 2020-07-02T12:30:47Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1107-0625 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1591 | |
dc.description.abstract | Purpose: The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of the expression of the Bcl-2 marker in healthy individuals (H), patients with OLP and patients with squamous cell carcinoma (SCC), and to establish potential interdependence between expression of Bcl-2 and the different clinical and histopathological parameters in H, OLP, and SCC. Methods: Immunohistochemistry for Bcl-2 was carried out using an avidin-biotin peroxidase complex method. Tissue sections were treated with mouse monoclonal antibody against Bcl-2 (124, DAKO A/S, Denmark; dilution 1/100). Immunohistochemical parameters measured included total tissue area, total stained area and intensity of stain. Results: Keratinocytes were not Bcl-2 positive in H and were sparsely positive in OLP. The number of lymphocytes stained with Bcl-2 was significantly lower in Has compared to patients with SCC and OLP. Bcl-2 staining was weak to moderate in OLP, and moderate to intense in SCC. Bcl-2-positive lymphocytes were more expressed in older OLP patients (>55 years), and in OLP specimens with orthokeratinized epithelium, less developed acanthosis and highest grade of lymphocyte expression. Conclusion: Bcl-2 may not serve as a prognostic biomarker in oral cancer development from OLP, but it could help in selecting patients with higher need of follow up to prevent malignancy. | en |
dc.publisher | Balkan Union of Oncology (B.U.ON.) | |
dc.relation | The Laboratory of Oral Pathology, "Pasteur" Hospital, Nice, France | |
dc.rights | restrictedAccess | |
dc.source | Journal of BUON | |
dc.subject | Bcl-2 | en |
dc.subject | oral lichen planus | en |
dc.subject | premalignant lesion | en |
dc.subject | squamous cell carcinoma | en |
dc.title | Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Чакић, Саша; Ђурић, М.; Јанковић, Љиљана; Хаджи-Михаиловић, Милош; Раyбауд, Хелене; Монтеи, Р.; | |
dc.citation.volume | 15 | |
dc.citation.issue | 2 | |
dc.citation.spage | 362 | |
dc.citation.epage | 368 | |
dc.citation.other | 15(2): 362-368 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000279655900025 | |
dc.identifier.pmid | 20658736 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_smile_1591 | |
dc.type.version | publishedVersion |
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