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dc.creatorRoganović, Jelena
dc.creatorRadenković, Miroslav
dc.creatorStojić, Dragica
dc.date.accessioned2020-07-02T12:30:51Z
dc.date.available2020-07-02T12:30:51Z
dc.date.issued2010
dc.identifier.issn0003-9969
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1592
dc.description.abstractObjectives: The influence of carotid artery occlusion (10, 30 and 60 min) on regulatory mechanisms implicated in the vasorelaxant responses of isolated glandular branch of rabbit facial artery to acetylcholine (ACh) and vasoactive intestinal polypeptide (VIP) was examined. Design: In organ bath studies with arterial rings precontracted with phenylephrine (1 mu M), before and after carotid artery occlusion, changes in isometric tension were recorded. Results: Endothelium-dependent vasorelaxation by ACh and endothelium-independent vasorelaxation by VIP were significantly reduced, started from 30 and 10 mm of carotid occlusion, respectively. Inhibitory effect of indomethacin on ACh vasorelaxation was enhanced whilst effect of N-G-nitro-L-arginine reduced, started from 30 min of carotid occlusion. Sodium nitroprusside-induced vasorelaxation was not changed after carotid occlusion. Inhibition of VIP vasorelaxation by L-N-omega-nitroarginine-2,4-L-diaminobutyric-amide, was reduced, started from 30 min of carotid occlusion. Forskolin enhanced VIP-induced vasorelaxation in control rings but this effect was reduced started from 30 min of occlusion. In the presence of VIP, vasorelaxant effect of ACh was increased; the increase was reduced, started from 10 min of carotid occlusion. Conclusions: The present investigation provides evidence for the decreased responsiveness to both, ACh-endothelium-dependent and VIP-endothelium-independent vasorelaxation in rabbit facial artery after carotid occlusion. In addition, the data suggest that ischaemia alters contribution of endothelial nitric oxide (eNO) and prostaglandin to ACh, and vascular smooth muscle's cAMP and neuronal NO to VIP vasorelaxant effects.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145015/RS//
dc.rightsrestrictedAccess
dc.sourceArchives of Oral Biology
dc.subjectAcetylcholineen
dc.subjectVasoactive intestinal polypeptideen
dc.subjectFacial arteryen
dc.subjectCarotid occlusionen
dc.titleACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојић, Драгица; Рогановић, Јелена; Раденковић, Мирослав;
dc.citation.volume55
dc.citation.issue5
dc.citation.spage333
dc.citation.epage342
dc.citation.other55(5): 333-342
dc.citation.rankM22
dc.identifier.wos000278174700001
dc.identifier.doi10.1016/j.archoralbio.2010.03.006
dc.identifier.pmid20359690
dc.identifier.scopus2-s2.0-77950917353
dc.identifier.rcubconv_2890
dc.type.versionpublishedVersion


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