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Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition
dc.creator | Petković, A. B. | |
dc.creator | Matić, S. M. | |
dc.creator | Stamatović, Novak | |
dc.creator | Vojvodić, Danilo | |
dc.creator | Todorović, T. M. | |
dc.creator | Lazić, Z. R. | |
dc.creator | Kozomara, Ružica | |
dc.date.accessioned | 2020-07-02T12:30:59Z | |
dc.date.available | 2020-07-02T12:30:59Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0901-5027 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1594 | |
dc.description.abstract | Analysis of pen-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in pen-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from pen-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the control group (healthy patients) have significantly lower concentrations of IL-1 beta, TNF-alpha, IL-8 and MIP-1 alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1 beta and TNF-alpha and between MIP-1 alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure. | en |
dc.publisher | Churchill Livingstone, Edinburgh | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Oral & Maxillofacial Surgery | |
dc.subject | cytokine | en |
dc.subject | dental implants | en |
dc.subject | peri-implantitis | en |
dc.title | Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Матић, С. М.; Војводић, Данило; Тодоровић, Т. М.; Лазић, З. Р.; Петковић, A. Б.; Козомара, Ружица; Стаматовић, Новак; | |
dc.citation.volume | 39 | |
dc.citation.issue | 5 | |
dc.citation.spage | 478 | |
dc.citation.epage | 485 | |
dc.citation.other | 39(5): 478-485 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000278584400011 | |
dc.identifier.doi | 10.1016/j.ijom.2010.01.014 | |
dc.identifier.pmid | 20207110 | |
dc.identifier.scopus | 2-s2.0-77952238280 | |
dc.type.version | publishedVersion |