Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis
Samo za registrovane korisnike
2010
Autori
Pavlović, SanjaStević, Zorica
Milovanović, Branislav
Miličić, Biljana
Rakocević-Stojanović, Vidosava
Lavrnić, Dragana
Apostolski, Slobodan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The aim of this study was to investigate autonomic cardiac control in patients with amyotrophic lateral sclerosis (ALS). Fifty-five patients with sporadic ALS (28 female and 27 male; average age 56.00 +/- 10.34 years) were compared to 30 healthy controls (17 female and 13 male; average age 42.87 +/- 11.91 years). Patients with previous history of cardiac disease, diabetes mellitus, and impaired respiratory function were excluded from the study. Cardiovascular autonomic tests according to Ewing, power spectrum analysis of RR variability (low- and high-frequency bands - LF and HF, LF/HF index), real-time beat-to-beat ECG signal monitoring with heart rate variability analysis and baroreflex function analysis were carried out in all patients. Time-domain parameters of heart rate variability (mean RR interval, SDNN, SDANN, SDNN index, rMSSD and pNN50%) were obtained from 24-h ECG monitoring. ALS patients had a significantly higher score of sympathetic (p lt 0.01) and parasympathetic (p l...t 0.001) dysfunction, as well as of the overall score of autonomic dysfunction (p lt 0.001). LF/HF index was significantly increased; baroreflex sensitivity and time-domain parameters of heart rate variability were highly significantly decreased in ALS patients (p lt 0.001). Our results demonstrated impaired cardiac autonomic control in ALS with marked parasympathetic dysfunction and sympathetic predominance.
Izvor:
Amyotrophic Lateral Sclerosis, 2010, 11, 3, 272-276Izdavač:
- Informa Healthcare, London
DOI: 10.3109/17482960903390855
ISSN: 1748-2968
PubMed: 20001491
WoS: 000277225200003
Scopus: 2-s2.0-77952126794
Kolekcije
Institucija/grupa
Stomatološki fakultetTY - JOUR AU - Pavlović, Sanja AU - Stević, Zorica AU - Milovanović, Branislav AU - Miličić, Biljana AU - Rakocević-Stojanović, Vidosava AU - Lavrnić, Dragana AU - Apostolski, Slobodan PY - 2010 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1598 AB - The aim of this study was to investigate autonomic cardiac control in patients with amyotrophic lateral sclerosis (ALS). Fifty-five patients with sporadic ALS (28 female and 27 male; average age 56.00 +/- 10.34 years) were compared to 30 healthy controls (17 female and 13 male; average age 42.87 +/- 11.91 years). Patients with previous history of cardiac disease, diabetes mellitus, and impaired respiratory function were excluded from the study. Cardiovascular autonomic tests according to Ewing, power spectrum analysis of RR variability (low- and high-frequency bands - LF and HF, LF/HF index), real-time beat-to-beat ECG signal monitoring with heart rate variability analysis and baroreflex function analysis were carried out in all patients. Time-domain parameters of heart rate variability (mean RR interval, SDNN, SDANN, SDNN index, rMSSD and pNN50%) were obtained from 24-h ECG monitoring. ALS patients had a significantly higher score of sympathetic (p lt 0.01) and parasympathetic (p lt 0.001) dysfunction, as well as of the overall score of autonomic dysfunction (p lt 0.001). LF/HF index was significantly increased; baroreflex sensitivity and time-domain parameters of heart rate variability were highly significantly decreased in ALS patients (p lt 0.001). Our results demonstrated impaired cardiac autonomic control in ALS with marked parasympathetic dysfunction and sympathetic predominance. PB - Informa Healthcare, London T2 - Amyotrophic Lateral Sclerosis T1 - Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis VL - 11 IS - 3 SP - 272 EP - 276 DO - 10.3109/17482960903390855 ER -
@article{ author = "Pavlović, Sanja and Stević, Zorica and Milovanović, Branislav and Miličić, Biljana and Rakocević-Stojanović, Vidosava and Lavrnić, Dragana and Apostolski, Slobodan", year = "2010", abstract = "The aim of this study was to investigate autonomic cardiac control in patients with amyotrophic lateral sclerosis (ALS). Fifty-five patients with sporadic ALS (28 female and 27 male; average age 56.00 +/- 10.34 years) were compared to 30 healthy controls (17 female and 13 male; average age 42.87 +/- 11.91 years). Patients with previous history of cardiac disease, diabetes mellitus, and impaired respiratory function were excluded from the study. Cardiovascular autonomic tests according to Ewing, power spectrum analysis of RR variability (low- and high-frequency bands - LF and HF, LF/HF index), real-time beat-to-beat ECG signal monitoring with heart rate variability analysis and baroreflex function analysis were carried out in all patients. Time-domain parameters of heart rate variability (mean RR interval, SDNN, SDANN, SDNN index, rMSSD and pNN50%) were obtained from 24-h ECG monitoring. ALS patients had a significantly higher score of sympathetic (p lt 0.01) and parasympathetic (p lt 0.001) dysfunction, as well as of the overall score of autonomic dysfunction (p lt 0.001). LF/HF index was significantly increased; baroreflex sensitivity and time-domain parameters of heart rate variability were highly significantly decreased in ALS patients (p lt 0.001). Our results demonstrated impaired cardiac autonomic control in ALS with marked parasympathetic dysfunction and sympathetic predominance.", publisher = "Informa Healthcare, London", journal = "Amyotrophic Lateral Sclerosis", title = "Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis", volume = "11", number = "3", pages = "272-276", doi = "10.3109/17482960903390855" }
Pavlović, S., Stević, Z., Milovanović, B., Miličić, B., Rakocević-Stojanović, V., Lavrnić, D.,& Apostolski, S.. (2010). Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis. in Amyotrophic Lateral Sclerosis Informa Healthcare, London., 11(3), 272-276. https://doi.org/10.3109/17482960903390855
Pavlović S, Stević Z, Milovanović B, Miličić B, Rakocević-Stojanović V, Lavrnić D, Apostolski S. Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis. in Amyotrophic Lateral Sclerosis. 2010;11(3):272-276. doi:10.3109/17482960903390855 .
Pavlović, Sanja, Stević, Zorica, Milovanović, Branislav, Miličić, Biljana, Rakocević-Stojanović, Vidosava, Lavrnić, Dragana, Apostolski, Slobodan, "Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis" in Amyotrophic Lateral Sclerosis, 11, no. 3 (2010):272-276, https://doi.org/10.3109/17482960903390855 . .