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dc.creatorBrinkmann, Ole
dc.creatorKastratović, Dragana A.
dc.creatorDimitrijević, Milovan
dc.creatorKonstantinović, Vitomir
dc.creatorJelovac, Drago
dc.creatorAntić, Jadranka
dc.creatorNesić, Vladimir S.
dc.creatorMarković, Srđan Z.
dc.creatorMartinović, Željko
dc.creatorAkin, David
dc.creatorSpielmann, Nadine
dc.creatorZhou, Hui
dc.creatorWong, David T.
dc.date.accessioned2020-07-02T12:31:53Z
dc.date.available2020-07-02T12:31:53Z
dc.date.issued2011
dc.identifier.issn1368-8375
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1608
dc.description.abstractEarly detection of oral squamous cell cancer (OSCC) is the key to improve the low 5-year survival rate. Using proteomic and genomic technologies we have previously discovered and validated salivary OSCC markers in American patients. The question arises whether these biomarkers are discriminatory in cohorts of different ethnic background. Six transcriptome (DUSP1, IL8, IL1B, OAZ1, SAT1, and S100P) and three proteome (IL1B, IL8, and M2BP) biomarkers were tested on 18 early and 17 late stage OSCC patients and 51 healthy controls with quantitative PCR and ELISA. Four transcriptome (IL8, IL1B, SAT1, and S100P) and all proteome biomarkers were significantly elevated (p lt 0.05) in OSCC patients. The combination of markers yielded an AUC of 0.86, 0.85 and 0.88 for OSCC total, T1-T2, and T3-T4, respectively. The sensitivity/specificity for OSCC total was 0.89/0.78, for T1-T2 0.67/0.96, and for T3-T4 0.82/0.84. In conclusion, seven of the nine salivary biomarkers (three proteins and four mRNAs) were validated and performed strongest in late stage cancer. Patient-based salivary diagnostics is a highly promising approach for OSCC detection. This study shows that previously discovered and validated salivary OSCC biomarkers are discriminatory and reproducible in a different ethnic cohort. These findings support the feasibility to implement multi-center, multi-ethnicity clinical trials towards the pivotal validation of salivary biomarkers for OSCC detection.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationNational Institute of Dental Research/National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 DE017170]
dc.rightsopenAccess
dc.sourceOral Oncology
dc.subjectOral canceren
dc.subjectBiomarkersen
dc.subjectSalivary diagnosticsen
dc.subjectProteomeen
dc.subjectTranscriptomeen
dc.titleOral squamous cell carcinoma detection by salivary biomarkers in a Serbian populationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКонстантиновић, Витомир; Зхоу, Хуи; Спиелманн, Надине; Aкин, Давид; Марковић, Срђан З.; Несић, Владимир С.; Димитријевић, Милован; Кастратовић, Драгана A.; Бринкманн, Оле; Мартиновић, Жељко; Wонг, Давид Т.; Aнтић, Јадранка; Јеловац, Драго;
dc.citation.volume47
dc.citation.issue1
dc.citation.spage51
dc.citation.epage55
dc.citation.other47(1): 51-55
dc.citation.rankaM21
dc.identifier.wos000286872500010
dc.identifier.doi10.1016/j.oraloncology.2010.10.009
dc.identifier.pmid21109482
dc.identifier.scopus2-s2.0-79551513238
dc.identifier.fulltexthttp://smile.stomf.bg.ac.rs/bitstream/id/373/1603.pdf
dc.identifier.rcubconv_2923
dc.type.versionpublishedVersion


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