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Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs
dc.creator | Jung, Ronald | |
dc.creator | Koković, Vladimir | |
dc.creator | Jurišić, Milan | |
dc.creator | Yaman, Duygu | |
dc.creator | Subramani, Karthikeyan | |
dc.creator | Weber, Franz E. | |
dc.date.accessioned | 2020-07-02T12:32:00Z | |
dc.date.available | 2020-07-02T12:32:00Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0905-7161 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1610 | |
dc.description.abstract | Objectives: The aim of the present study was to compare a newly developed biodegradable polylactide/polyglycolide/N-methyl-2-pyrrolidone (PLGA/NMP) membrane with a standard resorbable collagen membrane (RCM) in combination with and without the use of a bone substitute material (deproteinized bovine bone mineral [DBBM]) looking at the proposed tenting effect and bone regeneration. Materials and methods: In five adult German sheepdogs, the mandibular premolars P2, P3, P4, and the molar M1 were bilaterally extracted creating two bony defects on each site. A total of 20 dental implants were inserted and allocated to four different treatment modalities within each dog: PLGA/NMP membrane only (Test 1), PLGA/NMP membrane with DBBM (Test 2), RCM only (negative control), and RCM with DBBM (positive control). A histomorphometric analysis was performed 12 weeks after implantation. For statistical analysis, a Friedman test and subsequently a Wilcoxon signed ranks test were applied. Results: In four out of five PLGA/NMP membrane-treated defects, the membranes had broken into pieces without the support of DBBM. This led to a worse outcome than in the RCM group. In combination with DBBM, both membranes revealed similar amounts of area of bone regeneration and bone-to-implant contact without significant differences. On the level of the third implant thread, the PLGA/NMP membrane induced more horizontal bone formation beyond the graft than the RCM. Conclusion: The newly developed PLGA/NMP membrane performs equally well as the RCM when applied in combination with DBBM. Without bone substitute material, the PLGA/NMP membrane performed worse than the RCM in challenging defects, and therefore, a combination with a bone substitute material is recommended. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | University of Zurich | |
dc.relation | University of Belgrade | |
dc.rights | openAccess | |
dc.source | Clinical Oral Implants Research | |
dc.subject | dog study | en |
dc.subject | guided bone regeneration | en |
dc.subject | PLGA membrane | en |
dc.title | Guided bone regeneration with a synthetic biodegradable membrane: a comparative study in dogs | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јунг, Роналд; Wебер, Франз Е.; Јуришић, Милан; Субрамани, Картхикеyан; Коковић, Владимир; Yаман, Дуyгу; | |
dc.citation.volume | 22 | |
dc.citation.issue | 8 | |
dc.citation.spage | 802 | |
dc.citation.epage | 807 | |
dc.citation.other | 22(8): 802-807 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000292605600003 | |
dc.identifier.doi | 10.1111/j.1600-0501.2010.02068.x | |
dc.identifier.pmid | 21198905 | |
dc.identifier.scopus | 2-s2.0-79960234809 | |
dc.identifier.fulltext | https://smile.stomf.bg.ac.rs/bitstream/id/3312/1605.pdf | |
dc.type.version | publishedVersion |