Role of periodontal bacteria in development of abdominal aortic aneurysms

Abstract

Among many theories trying to explain abdominal aortic aneurysm (AAA) formation and progression, an infective theory has been proposed. Recently, it has been suggested that transient bacteremia, caused by numerous gram-negative microorganisms in periodontal infection, can play role in abdominal aortic aneurysm development. It is still unclear whether the presence of periodontal bacteria is just secondary phenomenon or they initiate aneurysm formation. Determining the nature of the relationship between infection and AAA may introduce antibiotics as a therapeutic and prophylactic option for abdominal aortic aneurysm treatment.

Pored brojnih teorija, kojima je pokušano da se objasni nastanak i progresija aneurizmi abdominalne aorte (AAA), predložena je iinfektivna teorija nastanka. Nedavno je sugerisano da tranzitorna bakterijemija, uzrokovana brojnim gram-negativnim mikroorganizmima tokom periodontalne infekcije, može da igra značajnu ulogu u nastanku aneurizme abdominalne aorte. I dalje je nejasno, da li je prisustvo periodontalnih bakterija samo sekundarni fenomen ili one iniciraju formiranje aneurizme. Odredjivanje prirode veze izmedju infekcije i AAA omogućiće potencijalno terapijsko i profilaktičko delovanje antibiotika u tretmanu anurizme abdominalne aorte.