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dc.creatorBasta-Jovanović, Gordana
dc.creatorRadojević-Škodrić, Sanja
dc.creatorBrašanac, Dimitrije
dc.creatorĐuricić, S.
dc.creatorMilašin, Jelena
dc.creatorBogdanović, L.
dc.creatorOprić, D.
dc.creatorSavin, M.
dc.creatorBaralić, I.
dc.creatorJovanović, M.
dc.date.accessioned2020-07-02T12:41:02Z
dc.date.available2020-07-02T12:41:02Z
dc.date.issued2012
dc.identifier.issn1107-0625
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1747
dc.description.abstractPurpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.en
dc.publisherBalkan Union of Oncology (B.U.ON.)
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175059/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of BUON
dc.subjectapoptosisen
dc.subjectexpressionen
dc.subjectprognostic valueen
dc.subjectsurvivinen
dc.subjectWilms tumoren
dc.titlePrognostic value of survivin expression in Wilms tumoren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБаралић, И.; Јовановић, М.; Опрић, Д.; Савин, М.; Богдановић, Л.; Брашанац, Димитрије; Милашин, Јелена; Ђурицић, С.; Баста-Јовановић, Гордана; Радојевић-Шкодрић, Сања;
dc.citation.volume17
dc.citation.issue1
dc.citation.spage168
dc.citation.epage173
dc.citation.other17(1): 168-173
dc.citation.rankM23
dc.identifier.wos000302503700028
dc.identifier.pmid22517713
dc.identifier.rcubconv_2987
dc.type.versionpublishedVersion


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