PURPOSE: The aim of this study was to investigate the histomorphological changes of the infraorbital nerve of rats treated with ampicillin. MATERIALS AND METHODS: The infraorbital nerve was approached through the infraorbital foramen, and 0.01 ml of ampicillin dissolved in distilled water was injected taking care not to damage the nerve. Saline solution was used in control animals. Nerves were dissected and after routine histology processing analysed by light microscopy. RESULTS: Cross-section of the nerve treated with ampicillin showed damaged axons with disintegration of heavily myelinated fibres, while thinly myelinated fibres remain unaffected. In the saline group, no damage was observed. The signs of regeneration of the damaged infraorbital nerves were detected on the fourth postoperative week. CONCLUSION: Ampicillin can cause peripheral nerve damage when injected perineurally. J Oral Pathol Med (2012) 41: 268-271
Keywords:
ampicillin / infraorbital nerve / rat
Source:
Journal of Oral Pathology & Medicine, 2012, 41, 3, 268-271
TY - JOUR
AU - Saulacić, Nikola
AU - Lombardi, Tommaso
AU - Stojčev-Stajčić, Ljiljana
AU - Iizuka, Tateyuki
AU - Stajčić, Zoran
PY - 2012
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1750
AB - PURPOSE: The aim of this study was to investigate the histomorphological changes of the infraorbital nerve of rats treated with ampicillin. MATERIALS AND METHODS: The infraorbital nerve was approached through the infraorbital foramen, and 0.01 ml of ampicillin dissolved in distilled water was injected taking care not to damage the nerve. Saline solution was used in control animals. Nerves were dissected and after routine histology processing analysed by light microscopy. RESULTS: Cross-section of the nerve treated with ampicillin showed damaged axons with disintegration of heavily myelinated fibres, while thinly myelinated fibres remain unaffected. In the saline group, no damage was observed. The signs of regeneration of the damaged infraorbital nerves were detected on the fourth postoperative week. CONCLUSION: Ampicillin can cause peripheral nerve damage when injected perineurally. J Oral Pathol Med (2012) 41: 268-271
PB - Wiley, Hoboken
T2 - Journal of Oral Pathology & Medicine
T1 - Neurolytic effects of ampicillin on the rat infraorbital nerve
VL - 41
IS - 3
SP - 268
EP - 271
DO - 10.1111/j.1600-0714.2011.01098.x
ER -
@article{
author = "Saulacić, Nikola and Lombardi, Tommaso and Stojčev-Stajčić, Ljiljana and Iizuka, Tateyuki and Stajčić, Zoran",
year = "2012",
abstract = "PURPOSE: The aim of this study was to investigate the histomorphological changes of the infraorbital nerve of rats treated with ampicillin. MATERIALS AND METHODS: The infraorbital nerve was approached through the infraorbital foramen, and 0.01 ml of ampicillin dissolved in distilled water was injected taking care not to damage the nerve. Saline solution was used in control animals. Nerves were dissected and after routine histology processing analysed by light microscopy. RESULTS: Cross-section of the nerve treated with ampicillin showed damaged axons with disintegration of heavily myelinated fibres, while thinly myelinated fibres remain unaffected. In the saline group, no damage was observed. The signs of regeneration of the damaged infraorbital nerves were detected on the fourth postoperative week. CONCLUSION: Ampicillin can cause peripheral nerve damage when injected perineurally. J Oral Pathol Med (2012) 41: 268-271",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "Neurolytic effects of ampicillin on the rat infraorbital nerve",
volume = "41",
number = "3",
pages = "268-271",
doi = "10.1111/j.1600-0714.2011.01098.x"
}
Saulacić, N., Lombardi, T., Stojčev-Stajčić, L., Iizuka, T.,& Stajčić, Z.. (2012). Neurolytic effects of ampicillin on the rat infraorbital nerve. in Journal of Oral Pathology & Medicine
Wiley, Hoboken., 41(3), 268-271.
https://doi.org/10.1111/j.1600-0714.2011.01098.x
Saulacić N, Lombardi T, Stojčev-Stajčić L, Iizuka T, Stajčić Z. Neurolytic effects of ampicillin on the rat infraorbital nerve. in Journal of Oral Pathology & Medicine. 2012;41(3):268-271.
doi:10.1111/j.1600-0714.2011.01098.x .
Saulacić, Nikola, Lombardi, Tommaso, Stojčev-Stajčić, Ljiljana, Iizuka, Tateyuki, Stajčić, Zoran, "Neurolytic effects of ampicillin on the rat infraorbital nerve" in Journal of Oral Pathology & Medicine, 41, no. 3 (2012):268-271,
https://doi.org/10.1111/j.1600-0714.2011.01098.x . .
