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dc.creatorMiletić, Maja
dc.creatorStojanović, R.
dc.creatorPajić, O.
dc.creatorBugarski, Diana
dc.creatorMojsilović, S.
dc.creatorCokić, V.
dc.creatorMilenković, P.
dc.date.accessioned2020-07-02T12:41:49Z
dc.date.available2020-07-02T12:41:49Z
dc.date.issued2012
dc.identifier.issn0971-5916
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1759
dc.description.abstractBackground & objectives: The interleukin (IL)-17 producing T-helper cells have been linked to pathogenesis of autoimmunity and mostly investigated in rheumatoid arthritis (RA). In this study we tested the IL-17 levels, as well as the levels of nitric oxide (NO) as possible IL-17-induced product, in patients with primary Sjogren's syndrome (pSS), an intricate and complex chronic autoimmune disorder of exocrine glands. Methods: Serum IL-17 levels and nitrite concentrations determined in patients with pSS (n=30) were compared with the values obtained in patients with RA (n=10) and healthy controls (n=15). The values obtained for 11,17 in pSS patients were also associated with the patients' clinical characteristics, particularly the rheumatoid factor (RF) and total antinuclear antibodies (tANA) levels. Results: Serum concentrations of IL-17 were significantly (P lt 0.01) higher in patients with pSS (12.9 +/- 28.0 pg/ml) as compared to those obtained in healthy individuals (0.2 +/- 0.6 pg/ml), but not as high as the values obtained for the patients with RA (34.5 +/- 56.2 pg/ml). The mean IL-17 levels were significantly (P lt 0.05) higher in the pSS patients positive for rheumatoid factor (20.3 +/- 33.3 pg/ml) than in RF-negatives (0.3 +/- 0.6 pg/ml). Mean serum concentrations of IL-17 were also higher in antinuclear antibody (ANA)positive samples (19.8 +/- 33.5 pg/ml) in comparison to ANA-negative sera (1.1 +/- 3.1 pg/ml) (P lt 0.05). The NO levels also showed elevated values in both pSS and RA patients, as compared to the healthy controls, since mean nitrite levels in patients with pSS and RA were 38.2 +/- 29.2 mu M and 41.7 +/- 21.1 mu M, respectively, while those in healthy controls were significantly lower, at 19.2 +/- 10.5 mu M. Interpretation & conclusions: The findings of this study showed that there was increased IL-17 and NO production in patients with primary SS, especially if they had associated elevated rheumatoid factor and antinuclear antibody values.en
dc.publisherMedknow Publications & Media Pvt Ltd, Mumbai
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceIndian Journal of Medical Research
dc.subjectInterleukin-17en
dc.subjectnitric oxideen
dc.subjectprimary Sjogren's syndromeen
dc.subjectrheumatoid arthritisen
dc.titleSerum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndromeen
dc.typearticle
dc.rights.licenseBY-NC-SA
dcterms.abstractПајић, О.; Цокић, В.; Мојсиловић, С.; Милетић, Маја; Бугарски, Диана; Стојановић, Р.; Миленковић, П.;
dc.citation.volume135
dc.citation.issue4
dc.citation.spage513
dc.citation.epage519
dc.citation.other135(4): 513-519
dc.citation.rankM21
dc.identifier.wos000307206300011
dc.identifier.pmid22664499
dc.identifier.fulltexthttp://smile.stomf.bg.ac.rs/bitstream/id/5240/Serum_interleukin-17_pub_2012.pdf
dc.identifier.rcubconv_3008
dc.type.versionpublishedVersion


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