Tumor necrosis factor (TNF) which exerts its effects through two different receptors known as TNF-R1 and TNF-R2, is a major proinflammatory cytokine involved in the pathogenesis of different types of tumors. We have investigated whether polymorphisms in TNF-alpha (-308G>A), TNF receptor 1 (36A>G) and TNF receptor 2 (676T>G) genes modulate the susceptibility for oral squamous cell carcinomas (OSCCs) and basal cell carcinomas (BCCs) of the skin, two frequent types of head and neck cancers. Genotyping was done on 50 OSCC patients, 50 BCC patients and 60 healthy individuals, using PCR/RFLP. A significant difference in genotype and allele frequencies was found between patients and controls for the TNF-R2 polymorphism, in both OSCC and BCC. There was no statistically significant difference between patients and controls for TNF-alpha and TNF-R1 polymorphisms. Carriers of G allele had an approximately 2.5- and 5-fold higher risk for OSCC and BCC, respectively, in the Serbian population.
Keywords:
Gene polymorphisms / TNF-alpha / TNF-R1 / TNF-R2 / head and neck cancer
Source:
Archives of Biological Sciences, 2013, 65, 1, 387-393
TY - JOUR
AU - Kostić, Marija
AU - Nikolić, Nadja
AU - Ilić, Branislav
AU - Jelovac, Drago
AU - Trakilović, Slobodanka
AU - Božović, Maja
AU - Milašin, Jelena
PY - 2013
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1793
AB - Tumor necrosis factor (TNF) which exerts its effects through two different receptors known as TNF-R1 and TNF-R2, is a major proinflammatory cytokine involved in the pathogenesis of different types of tumors. We have investigated whether polymorphisms in TNF-alpha (-308G>A), TNF receptor 1 (36A>G) and TNF receptor 2 (676T>G) genes modulate the susceptibility for oral squamous cell carcinomas (OSCCs) and basal cell carcinomas (BCCs) of the skin, two frequent types of head and neck cancers. Genotyping was done on 50 OSCC patients, 50 BCC patients and 60 healthy individuals, using PCR/RFLP. A significant difference in genotype and allele frequencies was found between patients and controls for the TNF-R2 polymorphism, in both OSCC and BCC. There was no statistically significant difference between patients and controls for TNF-alpha and TNF-R1 polymorphisms. Carriers of G allele had an approximately 2.5- and 5-fold higher risk for OSCC and BCC, respectively, in the Serbian population.
PB - Srpsko biološko društvo, Beograd, i dr.
T2 - Archives of Biological Sciences
T1 - Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population
VL - 65
IS - 1
SP - 387
EP - 393
DO - 10.2298/ABS1301387K
ER -
@article{
author = "Kostić, Marija and Nikolić, Nadja and Ilić, Branislav and Jelovac, Drago and Trakilović, Slobodanka and Božović, Maja and Milašin, Jelena",
year = "2013",
abstract = "Tumor necrosis factor (TNF) which exerts its effects through two different receptors known as TNF-R1 and TNF-R2, is a major proinflammatory cytokine involved in the pathogenesis of different types of tumors. We have investigated whether polymorphisms in TNF-alpha (-308G>A), TNF receptor 1 (36A>G) and TNF receptor 2 (676T>G) genes modulate the susceptibility for oral squamous cell carcinomas (OSCCs) and basal cell carcinomas (BCCs) of the skin, two frequent types of head and neck cancers. Genotyping was done on 50 OSCC patients, 50 BCC patients and 60 healthy individuals, using PCR/RFLP. A significant difference in genotype and allele frequencies was found between patients and controls for the TNF-R2 polymorphism, in both OSCC and BCC. There was no statistically significant difference between patients and controls for TNF-alpha and TNF-R1 polymorphisms. Carriers of G allele had an approximately 2.5- and 5-fold higher risk for OSCC and BCC, respectively, in the Serbian population.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population",
volume = "65",
number = "1",
pages = "387-393",
doi = "10.2298/ABS1301387K"
}
Kostić, M., Nikolić, N., Ilić, B., Jelovac, D., Trakilović, S., Božović, M.,& Milašin, J.. (2013). Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 65(1), 387-393.
https://doi.org/10.2298/ABS1301387K
Kostić M, Nikolić N, Ilić B, Jelovac D, Trakilović S, Božović M, Milašin J. Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population. in Archives of Biological Sciences. 2013;65(1):387-393.
doi:10.2298/ABS1301387K .
Kostić, Marija, Nikolić, Nadja, Ilić, Branislav, Jelovac, Drago, Trakilović, Slobodanka, Božović, Maja, Milašin, Jelena, "Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population" in Archives of Biological Sciences, 65, no. 1 (2013):387-393,
https://doi.org/10.2298/ABS1301387K . .
