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dc.creatorKostić, Marija
dc.creatorNikolić, Nadja
dc.creatorIlić, Branislav
dc.creatorJelovac, Drago
dc.creatorTrakilović, Slobodanka
dc.creatorBožović, Maja
dc.creatorMilašin, Jelena
dc.date.accessioned2020-07-02T12:44:06Z
dc.date.available2020-07-02T12:44:06Z
dc.date.issued2013
dc.identifier.issn0354-4664
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1793
dc.description.abstractTumor necrosis factor (TNF) which exerts its effects through two different receptors known as TNF-R1 and TNF-R2, is a major proinflammatory cytokine involved in the pathogenesis of different types of tumors. We have investigated whether polymorphisms in TNF-alpha (-308G>A), TNF receptor 1 (36A>G) and TNF receptor 2 (676T>G) genes modulate the susceptibility for oral squamous cell carcinomas (OSCCs) and basal cell carcinomas (BCCs) of the skin, two frequent types of head and neck cancers. Genotyping was done on 50 OSCC patients, 50 BCC patients and 60 healthy individuals, using PCR/RFLP. A significant difference in genotype and allele frequencies was found between patients and controls for the TNF-R2 polymorphism, in both OSCC and BCC. There was no statistically significant difference between patients and controls for TNF-alpha and TNF-R1 polymorphisms. Carriers of G allele had an approximately 2.5- and 5-fold higher risk for OSCC and BCC, respectively, in the Serbian population.en
dc.publisherSrpsko biološko društvo, Beograd, i dr.
dc.rightsopenAccess
dc.sourceArchives of Biological Sciences
dc.subjectGene polymorphismsen
dc.subjectTNF-alphaen
dc.subjectTNF-R1en
dc.subjectTNF-R2en
dc.subjecthead and neck canceren
dc.titleAssociation of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian populationen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractМилашин, Јелена; Јеловац, Драго; Костић, Марија; Тракиловић, Слободанка; Божовић, Маја; Николић, Нађа; Илић, Бранислав;
dc.citation.volume65
dc.citation.issue1
dc.citation.spage387
dc.citation.epage393
dc.citation.other65(1): 387-393
dc.citation.rankM23
dc.identifier.wos000312046300045
dc.identifier.doi10.2298/ABS1301387K
dc.identifier.scopus2-s2.0-84873117553
dc.identifier.fulltexthttp://smile.stomf.bg.ac.rs/bitstream/id/504/1788.pdf
dc.identifier.rcubconv_2230
dc.type.versionpublishedVersion


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