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dc.creatorStanimirović, Dragan
dc.creatorZeljić, Katarina
dc.creatorJanković, Ljiljana
dc.creatorMagić, Marko
dc.creatorHadži-Mihailović, Miloš
dc.creatorMagić, Zvonko
dc.date.accessioned2020-07-02T12:45:44Z
dc.date.available2020-07-02T12:45:44Z
dc.date.issued2013
dc.identifier.issn0909-8836
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1818
dc.description.abstractThe aim of this study was to assess whether polymorphisms in toll-like receptor (TLR) and cluster of differentiation 14 (CD14) genes are associated with oral lichen planus (OLP) risk and clinical course of the disease. The study group consisted of 101 patients with confirmed OLP and 104 healthy blood donors without systemic or oral mucosal diseases. Single nucleotide polymorphisms of TLR2 (rs3804099), TLR3 (rs3775291 and rs5743312), TLR4 (rs4986790 and rs4986791), and CD14 (rs2569190) genes were genotyped using real-time PCR or PCR-restriction fragment length polymorphism (PCR-RFLP). The rs5743312 TLR3 gene polymorphism was associated with increased OLP risk in comparison with the wild type genotype (OR = 15.984, P = 0.011). No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene. The polymorphisms of the TLR3 gene were in linkage disequilibrium (D ' = 1, r(2) = 0.1). Identified haplotypes were not associated with the risk of OLP. The findings of the current study suggest that the TT genotype of the rs5743312 TLR3 gene polymorphism may play a significant role in the aetiology of OLP.en
dc.publisherWiley-Blackwell, Hoboken
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Oral Sciences
dc.subjectTLRsen
dc.subjectsingle nucleotide polymorphismsen
dc.subjectCD14en
dc.subjectoral lichen planusen
dc.titleTLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risken
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗељић, Катарина; Магић, Звонко; Станимировић, Драган; Јанковић, Љиљана; Магић, Марко; Хаджи-Михаиловић, Милош;
dc.citation.volume121
dc.citation.issue5
dc.citation.spage421
dc.citation.epage426
dc.citation.other121(5): 421-426
dc.citation.rankM22
dc.identifier.wos000324315700005
dc.identifier.doi10.1111/eos.12074
dc.identifier.pmid24028589
dc.identifier.scopus2-s2.0-84883787858
dc.identifier.rcubconv_3106
dc.type.versionpublishedVersion


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