The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys
Abstract
Background. Traumatic injuries of permanent teeth with incomplete root formation are frequent during childhood. Adequate therapy is important for the further destiny of teeth with damaged pulp. Objectives. To evaluate the effect of pulpotomy and high pulpotomy on the pulp and on root development, and the effect of platelet rich plasma (PRP) with hydroxyapatite (HAP) as a carrier and hydroxyapatite alone on apexogenesis. Material and Methods. The study included eight monkeys (Cercopithecus aethiops) in which high pulpotomies were performed on the mandibular lateral incisors and canines, and pulpotomies were performed on the mandibular central incisors and premolars. The materials used in the study were commercial HAP (Apatec (R), Stomygen) and PR? (prepared at the Torlak Institute of Immunology and Virology, Belgrade, Serbia). Histological and radiological evaluations were done six months after the treatment. Results. Considering the differences between HAP+PRP treated teeth in the pulp...otomy group and teeth in the high pulpotomy group, two times more root growth retardation was observed in the high pulpotomy group. In the high pulpotomy group, root growth retardation was less common in HAP+PRP treated teeth (42.9%) than in HAP treated teeth (50%). In the pulpotomy group, retardation of root development was also less common in HAP+PRP treated teeth (25%) compared to HAP treated teeth (50%). There were differences between the pulpotomy and high pulpotomy groups, but without statistical significance. Conclusions. The application of endogenous growth factors in conjunction with the preservation of dental pulp vitality can result in a good outcome for pulp therapy of injured teeth, which means successfully completed apexogenesis
Keywords:
platelet rich plasma / apexogenesis / pulpotomy / monkeysSource:
Advances in Clinical & Experimental Medicine, 2013, 22, 4, 469-479Funding / projects:
- Interraction of etiopathogenetic mechanisms of periodontal disease and periimplantitis with the systemic disorders of the present day (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41008)
- Genetic control and molecular mechanisms in malignant, inflammatory and developmental pathologies of the orofacial region (RS-MESTD-Basic Research (BR or ON)-175075)
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Stomatološki fakultetTY - JOUR AU - Petrović, Vanja AU - Pejčić, Nataša AU - Čakić, Saša PY - 2013 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1823 AB - Background. Traumatic injuries of permanent teeth with incomplete root formation are frequent during childhood. Adequate therapy is important for the further destiny of teeth with damaged pulp. Objectives. To evaluate the effect of pulpotomy and high pulpotomy on the pulp and on root development, and the effect of platelet rich plasma (PRP) with hydroxyapatite (HAP) as a carrier and hydroxyapatite alone on apexogenesis. Material and Methods. The study included eight monkeys (Cercopithecus aethiops) in which high pulpotomies were performed on the mandibular lateral incisors and canines, and pulpotomies were performed on the mandibular central incisors and premolars. The materials used in the study were commercial HAP (Apatec (R), Stomygen) and PR? (prepared at the Torlak Institute of Immunology and Virology, Belgrade, Serbia). Histological and radiological evaluations were done six months after the treatment. Results. Considering the differences between HAP+PRP treated teeth in the pulpotomy group and teeth in the high pulpotomy group, two times more root growth retardation was observed in the high pulpotomy group. In the high pulpotomy group, root growth retardation was less common in HAP+PRP treated teeth (42.9%) than in HAP treated teeth (50%). In the pulpotomy group, retardation of root development was also less common in HAP+PRP treated teeth (25%) compared to HAP treated teeth (50%). There were differences between the pulpotomy and high pulpotomy groups, but without statistical significance. Conclusions. The application of endogenous growth factors in conjunction with the preservation of dental pulp vitality can result in a good outcome for pulp therapy of injured teeth, which means successfully completed apexogenesis T2 - Advances in Clinical & Experimental Medicine T1 - The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys VL - 22 IS - 4 SP - 469 EP - 479 UR - https://hdl.handle.net/21.15107/rcub_smile_1823 ER -
@article{ author = "Petrović, Vanja and Pejčić, Nataša and Čakić, Saša", year = "2013", abstract = "Background. Traumatic injuries of permanent teeth with incomplete root formation are frequent during childhood. Adequate therapy is important for the further destiny of teeth with damaged pulp. Objectives. To evaluate the effect of pulpotomy and high pulpotomy on the pulp and on root development, and the effect of platelet rich plasma (PRP) with hydroxyapatite (HAP) as a carrier and hydroxyapatite alone on apexogenesis. Material and Methods. The study included eight monkeys (Cercopithecus aethiops) in which high pulpotomies were performed on the mandibular lateral incisors and canines, and pulpotomies were performed on the mandibular central incisors and premolars. The materials used in the study were commercial HAP (Apatec (R), Stomygen) and PR? (prepared at the Torlak Institute of Immunology and Virology, Belgrade, Serbia). Histological and radiological evaluations were done six months after the treatment. Results. Considering the differences between HAP+PRP treated teeth in the pulpotomy group and teeth in the high pulpotomy group, two times more root growth retardation was observed in the high pulpotomy group. In the high pulpotomy group, root growth retardation was less common in HAP+PRP treated teeth (42.9%) than in HAP treated teeth (50%). In the pulpotomy group, retardation of root development was also less common in HAP+PRP treated teeth (25%) compared to HAP treated teeth (50%). There were differences between the pulpotomy and high pulpotomy groups, but without statistical significance. Conclusions. The application of endogenous growth factors in conjunction with the preservation of dental pulp vitality can result in a good outcome for pulp therapy of injured teeth, which means successfully completed apexogenesis", journal = "Advances in Clinical & Experimental Medicine", title = "The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys", volume = "22", number = "4", pages = "469-479", url = "https://hdl.handle.net/21.15107/rcub_smile_1823" }
Petrović, V., Pejčić, N.,& Čakić, S.. (2013). The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys. in Advances in Clinical & Experimental Medicine, 22(4), 469-479. https://hdl.handle.net/21.15107/rcub_smile_1823
Petrović V, Pejčić N, Čakić S. The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys. in Advances in Clinical & Experimental Medicine. 2013;22(4):469-479. https://hdl.handle.net/21.15107/rcub_smile_1823 .
Petrović, Vanja, Pejčić, Nataša, Čakić, Saša, "The Influence of Different Therapeutic Modalities and Platelet Rich Plasma on Apexogenesis - a Preliminary Study in Monkeys" in Advances in Clinical & Experimental Medicine, 22, no. 4 (2013):469-479, https://hdl.handle.net/21.15107/rcub_smile_1823 .