Bone loss biomarkers associated with peri-implantitis. A cross-sectional study
Samo za registrovane korisnike
2013
Autori
Rakić, Mia
Leković, Vojislav
Nikolić-Jakoba, Nataša

Vojvodić, Danilo

Petković-Ćurčin, Aleksandra
Sanz, Mariano

Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites al...l three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.
Ključne reči:
biomarker / inflammation / OPG / osteoclastogenesis / peri-implantitis / periodontitis / RANK / RANKL / ratioIzvor:
Clinical Oral Implants Research, 2013, 24, 10, 1110-1116Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
DOI: 10.1111/j.1600-0501.2012.02518.x
ISSN: 0905-7161
PubMed: 22708989
WoS: 000323838400007
Scopus: 2-s2.0-84883557124
Kolekcije
Institucija/grupa
Stomatološki fakultetTY - JOUR AU - Rakić, Mia AU - Leković, Vojislav AU - Nikolić-Jakoba, Nataša AU - Vojvodić, Danilo AU - Petković-Ćurčin, Aleksandra AU - Sanz, Mariano PY - 2013 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1824 AB - Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis. PB - Wiley, Hoboken T2 - Clinical Oral Implants Research T1 - Bone loss biomarkers associated with peri-implantitis. A cross-sectional study VL - 24 IS - 10 SP - 1110 EP - 1116 DO - 10.1111/j.1600-0501.2012.02518.x ER -
@article{ author = "Rakić, Mia and Leković, Vojislav and Nikolić-Jakoba, Nataša and Vojvodić, Danilo and Petković-Ćurčin, Aleksandra and Sanz, Mariano", year = "2013", abstract = "Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.", publisher = "Wiley, Hoboken", journal = "Clinical Oral Implants Research", title = "Bone loss biomarkers associated with peri-implantitis. A cross-sectional study", volume = "24", number = "10", pages = "1110-1116", doi = "10.1111/j.1600-0501.2012.02518.x" }
Rakić, M., Leković, V., Nikolić-Jakoba, N., Vojvodić, D., Petković-Ćurčin, A.,& Sanz, M.. (2013). Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. in Clinical Oral Implants Research Wiley, Hoboken., 24(10), 1110-1116. https://doi.org/10.1111/j.1600-0501.2012.02518.x
Rakić M, Leković V, Nikolić-Jakoba N, Vojvodić D, Petković-Ćurčin A, Sanz M. Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. in Clinical Oral Implants Research. 2013;24(10):1110-1116. doi:10.1111/j.1600-0501.2012.02518.x .
Rakić, Mia, Leković, Vojislav, Nikolić-Jakoba, Nataša, Vojvodić, Danilo, Petković-Ćurčin, Aleksandra, Sanz, Mariano, "Bone loss biomarkers associated with peri-implantitis. A cross-sectional study" in Clinical Oral Implants Research, 24, no. 10 (2013):1110-1116, https://doi.org/10.1111/j.1600-0501.2012.02518.x . .