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dc.creatorRakić, Mia
dc.creatorLeković, Vojislav
dc.creatorNikolić-Jakoba, Nataša
dc.creatorVojvodić, Danilo
dc.creatorPetković-Ćurčin, Aleksandra
dc.creatorSanz, Mariano
dc.date.accessioned2020-07-02T12:46:08Z
dc.date.available2020-07-02T12:46:08Z
dc.date.issued2013
dc.identifier.issn0905-7161
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1824
dc.description.abstractAim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41008/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Oral Implants Research
dc.subjectbiomarkeren
dc.subjectinflammationen
dc.subjectOPGen
dc.subjectosteoclastogenesisen
dc.subjectperi-implantitisen
dc.subjectperiodontitisen
dc.subjectRANKen
dc.subjectRANKLen
dc.subjectratioen
dc.titleBone loss biomarkers associated with peri-implantitis. A cross-sectional studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВојводић, Данило; Николић-Јакоба, Наташа; Санз, Мариано; Петковић-Ћурчин, Aлександра; Ракић, Миа; Лековић, Војислав;
dc.citation.volume24
dc.citation.issue10
dc.citation.spage1110
dc.citation.epage1116
dc.citation.other24(10): 1110-1116
dc.citation.rankaM21
dc.identifier.wos000323838400007
dc.identifier.doi10.1111/j.1600-0501.2012.02518.x
dc.identifier.pmid22708989
dc.identifier.scopus2-s2.0-84883557124
dc.type.versionpublishedVersion


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