Приказ основних података о документу
Bone loss biomarkers associated with peri-implantitis. A cross-sectional study
dc.creator | Rakić, Mia | |
dc.creator | Leković, Vojislav | |
dc.creator | Nikolić-Jakoba, Nataša | |
dc.creator | Vojvodić, Danilo | |
dc.creator | Petković-Ćurčin, Aleksandra | |
dc.creator | Sanz, Mariano | |
dc.date.accessioned | 2020-07-02T12:46:08Z | |
dc.date.available | 2020-07-02T12:46:08Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0905-7161 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1824 | |
dc.description.abstract | Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41008/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Oral Implants Research | |
dc.subject | biomarker | en |
dc.subject | inflammation | en |
dc.subject | OPG | en |
dc.subject | osteoclastogenesis | en |
dc.subject | peri-implantitis | en |
dc.subject | periodontitis | en |
dc.subject | RANK | en |
dc.subject | RANKL | en |
dc.subject | ratio | en |
dc.title | Bone loss biomarkers associated with peri-implantitis. A cross-sectional study | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Војводић, Данило; Николић-Јакоба, Наташа; Санз, Мариано; Петковић-Ћурчин, Aлександра; Ракић, Миа; Лековић, Војислав; | |
dc.citation.volume | 24 | |
dc.citation.issue | 10 | |
dc.citation.spage | 1110 | |
dc.citation.epage | 1116 | |
dc.citation.other | 24(10): 1110-1116 | |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000323838400007 | |
dc.identifier.doi | 10.1111/j.1600-0501.2012.02518.x | |
dc.identifier.pmid | 22708989 | |
dc.identifier.scopus | 2-s2.0-84883557124 | |
dc.type.version | publishedVersion |