Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone
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2013
Authors
Juloski, Jovana
Glišić, Branislav

Šćepan, Ivana

Milašin, Jelena

Mitrović, Katarina
Babić, Marko
Article (Published version)

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The present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup c...ompared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention.
Keywords:
Turner syndrome / Growth hormone therapy / Craniofacial development / Bimaxillary retrognathismSource:
Clinical Oral Investigations, 2013, 17, 6, 1563-1571Publisher:
- Springer Heidelberg, Heidelberg
Projects:
DOI: 10.1007/s00784-012-0844-8
ISSN: 1432-6981
PubMed: 23001189
WoS: 000320887800014
Scopus: 2-s2.0-84879463238
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Stomatološki fakultetTY - JOUR AU - Juloski, Jovana AU - Glišić, Branislav AU - Šćepan, Ivana AU - Milašin, Jelena AU - Mitrović, Katarina AU - Babić, Marko PY - 2013 UR - http://smile.stomf.bg.ac.rs/handle/123456789/1828 AB - The present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup compared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention. PB - Springer Heidelberg, Heidelberg C3 - Clinical Oral Investigations T1 - Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone VL - 17 IS - 6 SP - 1563 EP - 1571 DO - 10.1007/s00784-012-0844-8 ER -
@article{ author = "Juloski, Jovana and Glišić, Branislav and Šćepan, Ivana and Milašin, Jelena and Mitrović, Katarina and Babić, Marko", year = "2013", url = "http://smile.stomf.bg.ac.rs/handle/123456789/1828", abstract = "The present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup compared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention.", publisher = "Springer Heidelberg, Heidelberg", journal = "Clinical Oral Investigations", title = "Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone", volume = "17", number = "6", pages = "1563-1571", doi = "10.1007/s00784-012-0844-8" }
Juloski J, Glišić B, Šćepan I, Milašin J, Mitrović K, Babić M. Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone. Clinical Oral Investigations. 2013;17(6):1563-1571
Juloski, J., Glišić, B., Šćepan, I., Milašin, J., Mitrović, K.,& Babić, M. (2013). Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone. Clinical Oral InvestigationsSpringer Heidelberg, Heidelberg., 17(6), 1563-1571. https://doi.org/10.1007/s00784-012-0844-8
Juloski Jovana, Glišić Branislav, Šćepan Ivana, Milašin Jelena, Mitrović Katarina, Babić Marko, "Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone" 17, no. 6 (2013):1563-1571, https://doi.org/10.1007/s00784-012-0844-8 .