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Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone

Authorized Users Only
2013
Authors
Juloski, Jovana
Glišić, Branislav
Šćepan, Ivana
Milašin, Jelena
Mitrović, Katarina
Babić, Marko
Article (Published version)
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Abstract
The present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup c...ompared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention.

Keywords:
Turner syndrome / Growth hormone therapy / Craniofacial development / Bimaxillary retrognathism
Source:
Clinical Oral Investigations, 2013, 17, 6, 1563-1571
Publisher:
  • Springer Heidelberg, Heidelberg
Funding / projects:
  • Genetic control and molecular mechanisms in malignant, inflammatory and developmental pathologies of the orofacial region (RS-175075)

DOI: 10.1007/s00784-012-0844-8

ISSN: 1432-6981

PubMed: 23001189

WoS: 000320887800014

Scopus: 2-s2.0-84879463238
[ Google Scholar ]
9
9
URI
https://smile.stomf.bg.ac.rs/handle/123456789/1828
Collections
  • Radovi istraživača
Institution/Community
Stomatološki fakultet
TY  - JOUR
AU  - Juloski, Jovana
AU  - Glišić, Branislav
AU  - Šćepan, Ivana
AU  - Milašin, Jelena
AU  - Mitrović, Katarina
AU  - Babić, Marko
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1828
AB  - The present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup compared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone
VL  - 17
IS  - 6
SP  - 1563
EP  - 1571
DO  - 10.1007/s00784-012-0844-8
ER  - 
@article{
author = "Juloski, Jovana and Glišić, Branislav and Šćepan, Ivana and Milašin, Jelena and Mitrović, Katarina and Babić, Marko",
year = "2013",
abstract = "The present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup compared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone",
volume = "17",
number = "6",
pages = "1563-1571",
doi = "10.1007/s00784-012-0844-8"
}
Juloski, J., Glišić, B., Šćepan, I., Milašin, J., Mitrović, K.,& Babić, M.. (2013). Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 17(6), 1563-1571.
https://doi.org/10.1007/s00784-012-0844-8
Juloski J, Glišić B, Šćepan I, Milašin J, Mitrović K, Babić M. Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone. in Clinical Oral Investigations. 2013;17(6):1563-1571.
doi:10.1007/s00784-012-0844-8 .
Juloski, Jovana, Glišić, Branislav, Šćepan, Ivana, Milašin, Jelena, Mitrović, Katarina, Babić, Marko, "Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone" in Clinical Oral Investigations, 17, no. 6 (2013):1563-1571,
https://doi.org/10.1007/s00784-012-0844-8 . .

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