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dc.creatorJuloski, Jovana
dc.creatorGlišić, Branislav
dc.creatorŠćepan, Ivana
dc.creatorMilašin, Jelena
dc.creatorMitrović, Katarina
dc.creatorBabić, Marko
dc.date.accessioned2020-07-02T12:46:24Z
dc.date.available2020-07-02T12:46:24Z
dc.date.issued2013
dc.identifier.issn1432-6981
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1828
dc.description.abstractThe present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup compared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Oral Investigations
dc.subjectTurner syndromeen
dc.subjectGrowth hormone therapyen
dc.subjectCraniofacial developmenten
dc.subjectBimaxillary retrognathismen
dc.titleOntogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormoneen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГлишић, Бранислав; Бабић, Марко; Шћепан, Ивана; Јулоски, Јована; Милашин, Јелена; Митровић, Катарина;
dc.citation.volume17
dc.citation.issue6
dc.citation.spage1563
dc.citation.epage1571
dc.citation.other17(6): 1563-1571
dc.citation.rankM21
dc.identifier.wos000320887800014
dc.identifier.doi10.1007/s00784-012-0844-8
dc.identifier.pmid23001189
dc.identifier.scopus2-s2.0-84879463238
dc.identifier.rcubconv_3093
dc.type.versionpublishedVersion


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