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dc.creatorDaković, Dragana
dc.creatorČolić, Miodrag
dc.creatorČakić, Saša
dc.creatorMileusnić, Ivan
dc.creatorHajduković, Zoran
dc.creatorStamatović, Novak
dc.date.accessioned2020-07-02T12:47:59Z
dc.date.available2020-07-02T12:47:59Z
dc.date.issued2013
dc.identifier.issn1053-4628
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1852
dc.description.abstractObjective: The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type I diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established Methods: Twenty children and adolescents with Type I DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p lt 0.005) elevated in subjects with Type 1 DM (474.47 +/- 716.76) compared to non-diabetic control group (101.99 +/- 68.32). There was no difference (p>0.05) in the salivary IL-8 level when subjects with Type I DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type I DM was correlated with the clinical parameters, no statistical significance was found Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.en
dc.publisherJournal Pedodontics Inc, Birmingham
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41008/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Clinical Pediatric Dentistry
dc.subjectType 1 diabetes mellitusen
dc.subjectperiodontitisen
dc.subjectchildrenen
dc.subjectcytokinesen
dc.subjectinterleukin-8en
dc.titleSalivary interleukin-8 levels in children suffering from Type 1 diabetes mellitusen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЧакић, Саша; Чолић, Миодраг; Стаматовић, Новак; Хајдуковић, Зоран; Даковић, Драгана; Милеуснић, Иван;
dc.citation.volume37
dc.citation.issue4
dc.citation.spage377
dc.citation.epage380
dc.citation.other37(4): 377-380
dc.citation.rankM23
dc.identifier.wos000335092800008
dc.identifier.doi10.17796/jcpd.37.4.l135531h4542gj66
dc.identifier.pmid24046985
dc.identifier.scopus2-s2.0-84885932613
dc.type.versionpublishedVersion


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