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dc.creatorPetrović, Nina
dc.creatorMandusić, Vesna
dc.creatorStanojević, Boban
dc.creatorLukić, Silvana
dc.creatorTodorović, Lidija
dc.creatorRoganović, Jelena
dc.creatorDimitrijević, Bogomir
dc.date.accessioned2020-07-02T12:48:27Z
dc.date.available2020-07-02T12:48:27Z
dc.date.issued2014
dc.identifier.issn1357-0560
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1859
dc.description.abstractMicroRNA-21 (miR-21) overexpression is characteristic for various types of tumors, but it is still unknown whether its expression levels differ between invasive and non-invasive breast carcinomas. The main goal of the study was to determine the difference in miR-21 expression among normal tissue, non-invasive, invasive with non-invasive component, and pure invasive breast cancer samples, to explain its potential role and significance in breast cancer invasiveness. The second goal was to propose miR-21 as molecular marker of breast cancer invasiveness and potential target for future anti-miR therapies for the prevention of invasion and metastasis. In order to reveal the role of miR-21 in breast cancer invasiveness, we measured miR-21 expression levels in 44 breast cancer and four normal samples by stem-loop real-time RT-PCR using TaqMan technology. Relative expression levels of miR-21 were significantly higher in invasive than in other groups (P = 0.002) and significantly higher in invasive compared with invasive with non-invasive component group in histological (P = 0.043) and nuclear grade 2 (P = 0.036), estrogen-receptor-positive (ER+) (P = 0.006), progesterone-receptor-positive (PR+) (P = 0.008), ER+ PR+ (P = 0.007), and proliferation index (Ki-67) lt = 20 % (P = 0.036) tumors. Our findings suggest that miR-21 could be independent molecular marker of breast cancer invasiveness and potential target for future anti-miR therapies for the prevention of invasion and metastasis.en
dc.publisherHumana Press Inc, Totowa
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS//
dc.rightsrestrictedAccess
dc.sourceMedical Oncology
dc.subjectBreast canceren
dc.subjectMicroRNAen
dc.subjectMiR-21 expression levelsen
dc.subjectInvasivenessen
dc.subjectTaqMan MicroRNA assayen
dc.subjectRT-qPCRen
dc.titleThe difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРогановић, Јелена; Лукић, Силвана; Петровић, Нина; Тодоровић, Лидија; Димитријевић, Богомир; Станојевић, Бобан; Мандусић, Весна;
dc.citation.volume31
dc.citation.issue3
dc.citation.other31(3): -
dc.citation.rankM22
dc.identifier.wos000337728700032
dc.identifier.doi10.1007/s12032-014-0867-x
dc.identifier.pmid24488617
dc.identifier.scopus2-s2.0-84893185212
dc.identifier.rcubconv_3183
dc.type.versionpublishedVersion


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