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The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion
dc.creator | Petrović, Nina | |
dc.creator | Mandusić, Vesna | |
dc.creator | Stanojević, Boban | |
dc.creator | Lukić, Silvana | |
dc.creator | Todorović, Lidija | |
dc.creator | Roganović, Jelena | |
dc.creator | Dimitrijević, Bogomir | |
dc.date.accessioned | 2020-07-02T12:48:27Z | |
dc.date.available | 2020-07-02T12:48:27Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1357-0560 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1859 | |
dc.description.abstract | MicroRNA-21 (miR-21) overexpression is characteristic for various types of tumors, but it is still unknown whether its expression levels differ between invasive and non-invasive breast carcinomas. The main goal of the study was to determine the difference in miR-21 expression among normal tissue, non-invasive, invasive with non-invasive component, and pure invasive breast cancer samples, to explain its potential role and significance in breast cancer invasiveness. The second goal was to propose miR-21 as molecular marker of breast cancer invasiveness and potential target for future anti-miR therapies for the prevention of invasion and metastasis. In order to reveal the role of miR-21 in breast cancer invasiveness, we measured miR-21 expression levels in 44 breast cancer and four normal samples by stem-loop real-time RT-PCR using TaqMan technology. Relative expression levels of miR-21 were significantly higher in invasive than in other groups (P = 0.002) and significantly higher in invasive compared with invasive with non-invasive component group in histological (P = 0.043) and nuclear grade 2 (P = 0.036), estrogen-receptor-positive (ER+) (P = 0.006), progesterone-receptor-positive (PR+) (P = 0.008), ER+ PR+ (P = 0.007), and proliferation index (Ki-67) lt = 20 % (P = 0.036) tumors. Our findings suggest that miR-21 could be independent molecular marker of breast cancer invasiveness and potential target for future anti-miR therapies for the prevention of invasion and metastasis. | en |
dc.publisher | Humana Press Inc, Totowa | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS// | |
dc.rights | restrictedAccess | |
dc.source | Medical Oncology | |
dc.subject | Breast cancer | en |
dc.subject | MicroRNA | en |
dc.subject | MiR-21 expression levels | en |
dc.subject | Invasiveness | en |
dc.subject | TaqMan MicroRNA assay | en |
dc.subject | RT-qPCR | en |
dc.title | The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Рогановић, Јелена; Лукић, Силвана; Петровић, Нина; Тодоровић, Лидија; Димитријевић, Богомир; Станојевић, Бобан; Мандусић, Весна; | |
dc.citation.volume | 31 | |
dc.citation.issue | 3 | |
dc.citation.other | 31(3): - | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000337728700032 | |
dc.identifier.doi | 10.1007/s12032-014-0867-x | |
dc.identifier.pmid | 24488617 | |
dc.identifier.scopus | 2-s2.0-84893185212 | |
dc.type.version | publishedVersion |