Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma
2014
Аутори
Ilic-Dimitrijević, IvanaLoening, Thomas
Falk, Marcus
Konstantinović, Vitomir
Vukadinović, Miroslav
Tepavčević, Zvezdana
Tabaković, Saša Z.
Pejčić, Nataša
Miličić, Biljana
Milašin, Jelena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and pro...gnostic marker for mucoepidermoid carcinomas.
Кључне речи:
Salivary gland / Mucoepidermoid carcinoma / Chromosomal translocation (11,19) / MECT1-MAML2 / RT-PCR diagnosticИзвор:
Genetika - Belgrade, 2014, 46, 2, 601-610Издавач:
- Društvo genetičara Srbije, Beograd
Финансирање / пројекти:
- Генетичка контрола и молекуларни механизми у малигним, инфламаторним и развојним патологијама орофацијалне регије (RS-MESTD-Basic Research (BR or ON)-175075)
- Institute of Haematopathology Hamburg, Hamburg, Germany
DOI: 10.2298/GENSR1402601D
ISSN: 0534-0012
WoS: 000342659500026
Scopus: 2-s2.0-84968911874
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Ilic-Dimitrijević, Ivana AU - Loening, Thomas AU - Falk, Marcus AU - Konstantinović, Vitomir AU - Vukadinović, Miroslav AU - Tepavčević, Zvezdana AU - Tabaković, Saša Z. AU - Pejčić, Nataša AU - Miličić, Biljana AU - Milašin, Jelena PY - 2014 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1926 AB - Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas. PB - Društvo genetičara Srbije, Beograd T2 - Genetika - Belgrade T1 - Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma VL - 46 IS - 2 SP - 601 EP - 610 DO - 10.2298/GENSR1402601D ER -
@article{ author = "Ilic-Dimitrijević, Ivana and Loening, Thomas and Falk, Marcus and Konstantinović, Vitomir and Vukadinović, Miroslav and Tepavčević, Zvezdana and Tabaković, Saša Z. and Pejčić, Nataša and Miličić, Biljana and Milašin, Jelena", year = "2014", abstract = "Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.", publisher = "Društvo genetičara Srbije, Beograd", journal = "Genetika - Belgrade", title = "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma", volume = "46", number = "2", pages = "601-610", doi = "10.2298/GENSR1402601D" }
Ilic-Dimitrijević, I., Loening, T., Falk, M., Konstantinović, V., Vukadinović, M., Tepavčević, Z., Tabaković, S. Z., Pejčić, N., Miličić, B.,& Milašin, J.. (2014). Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma. in Genetika - Belgrade Društvo genetičara Srbije, Beograd., 46(2), 601-610. https://doi.org/10.2298/GENSR1402601D
Ilic-Dimitrijević I, Loening T, Falk M, Konstantinović V, Vukadinović M, Tepavčević Z, Tabaković SZ, Pejčić N, Miličić B, Milašin J. Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma. in Genetika - Belgrade. 2014;46(2):601-610. doi:10.2298/GENSR1402601D .
Ilic-Dimitrijević, Ivana, Loening, Thomas, Falk, Marcus, Konstantinović, Vitomir, Vukadinović, Miroslav, Tepavčević, Zvezdana, Tabaković, Saša Z., Pejčić, Nataša, Miličić, Biljana, Milašin, Jelena, "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma" in Genetika - Belgrade, 46, no. 2 (2014):601-610, https://doi.org/10.2298/GENSR1402601D . .