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Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma
dc.creator | Ilic-Dimitrijević, Ivana | |
dc.creator | Loening, Thomas | |
dc.creator | Falk, Marcus | |
dc.creator | Konstantinović, Vitomir | |
dc.creator | Vukadinović, Miroslav | |
dc.creator | Tepavčević, Zvezdana | |
dc.creator | Tabaković, Saša Z. | |
dc.creator | Pejčić, Nataša | |
dc.creator | Miličić, Biljana | |
dc.creator | Milašin, Jelena | |
dc.date.accessioned | 2020-07-02T12:52:51Z | |
dc.date.available | 2020-07-02T12:52:51Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0534-0012 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/1926 | |
dc.description.abstract | Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas. | en |
dc.publisher | Društvo genetičara Srbije, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS// | |
dc.relation | Institute of Haematopathology Hamburg, Hamburg, Germany | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Genetika - Belgrade | |
dc.subject | Salivary gland | en |
dc.subject | Mucoepidermoid carcinoma | en |
dc.subject | Chromosomal translocation (11,19) | en |
dc.subject | MECT1-MAML2 | en |
dc.subject | RT-PCR diagnostic | en |
dc.title | Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Илиц-Димитријевић, Ивана; Константиновић, Витомир; Милашин, Јелена; Миличић, Биљана; Вукадиновић, Мирослав; Тепавчевић, Звездана; Табаковић, Саша З.; Пејчић, Наташа; Лоенинг, Тхомас; Фалк, Марцус; | |
dc.citation.volume | 46 | |
dc.citation.issue | 2 | |
dc.citation.spage | 601 | |
dc.citation.epage | 610 | |
dc.citation.other | 46(2): 601-610 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000342659500026 | |
dc.identifier.doi | 10.2298/GENSR1402601D | |
dc.identifier.scopus | 2-s2.0-84968911874 | |
dc.identifier.fulltext | https://smile.stomf.bg.ac.rs/bitstream/id/600/1921.pdf | |
dc.type.version | publishedVersion |