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dc.creatorPetrović, Nina
dc.creatorMandusić, Vesna
dc.creatorDimitrijević, Bogomir
dc.creatorRoganović, Jelena
dc.creatorLukić, Silvana
dc.creatorTodorović, Lidija
dc.creatorStanojević, Boban
dc.date.accessioned2020-07-02T12:53:08Z
dc.date.available2020-07-02T12:53:08Z
dc.date.issued2014
dc.identifier.issn1357-0560
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1930
dc.description.abstractMicroRNAs play essential role in breast carcinoma progression and invasion. Our principal goals were to assess clinicopathological and prognostic correlations of microRNA-21 (miR-21) expression levels in a group of 39 Serbian breast cancer patients with invasive lobular (ILC), ductal (IDC), or mixed (ILC-IDC) breast carcinomas and in order to discover the role of miR-21 in potential novel form of stratification of the patients with different estrogen receptor (ER) and progesterone receptor (PR) status. MiR-21 expression levels were measured by stem-loop real-time RT-PCR using TaqMan technology. ER, PR, human epidermal growth factor 2 receptor (Her-2), and proliferative index (Ki-67) were evaluated by immunohistochemistry. MiR-21 levels do not vary among ILC, IDC, and ILC-IDC subgroups. MiR-21 expression levels varied significantly in the age, tumor size, Ki-67, and different grade (p = 0.030, p = 0.036, p = 0.027 and p = 0.032, respectively) subgroups. ER? and PR? showed higher miR-21 levels than their negative receptor status paired groups ER-and PR-with p = 0.012 and p = 0.018, respectively. MiR-21 positively correlated with ER and PR status (p = 0.018, rho = 0.379 and p = 0.034, rho = 0.345, respectively). Our findings suggest that miR-21 emulates transitional form of expression and that the levels of expression might be useful for stratification of the patients with different receptor status with the purpose to seek for new therapy approaches especially for the patients with the lack of response to conventional endocrine therapy.en
dc.publisherHumana Press Inc, Totowa
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS//
dc.rightsrestrictedAccess
dc.sourceMedical Oncology
dc.subjectInvasive breast carcinomaen
dc.subjectMicro RNAen
dc.subjectMiR-21 expression levelsen
dc.subjectEstrogen receptor statusen
dc.subjectProgesterone receptor statusen
dc.titleHigher miR-21 expression in invasive breast carcinomas is associated with positive estrogen and progesterone receptor status in patients from Serbiaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛукић, Силвана; Димитријевић, Богомир; Мандусић, Весна; Рогановић, Јелена; Станојевић, Бобан; Тодоровић, Лидија; Петровић, Нина;
dc.citation.volume31
dc.citation.issue6
dc.citation.other31(6): -
dc.citation.rankM22
dc.identifier.wos000339003100014
dc.identifier.doi10.1007/s12032-014-0977-5
dc.identifier.pmid24781337
dc.identifier.scopus2-s2.0-84901738320
dc.type.versionpublishedVersion


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