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dc.creatorNikolić, Miloš
dc.creatorGlamočlija, Jasmina
dc.creatorFerreira, Isabel C. F. R.
dc.creatorCalhelha, Ricardo C.
dc.creatorFernandes, Angela
dc.creatorMarković, Tatjana
dc.creatorMarković, Dejan
dc.creatorGiweli, Abdulhamed
dc.creatorSoković, Marina
dc.date.accessioned2020-07-02T12:54:19Z
dc.date.available2020-07-02T12:54:19Z
dc.date.issued2014
dc.identifier.issn0926-6690
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1949
dc.description.abstractAromatic plant species of genus Thymus are important medicinal plants, highly recommended due to a range of therapeutic properties of their essential oils, commonly known as thyme oil: antirheumatic, antiseptic, antispasmodic, antimicrobial, cardiac, carminative, diuretic and expectorant. The oil is also beneficial in boosting the immune system and helps to fight colds, flu, infectious diseases and chills. It is proved to be a urinary antiseptic, being very helpful for cystitis and urethritis. Scientific validation of traditional uses, and phytochemical and bioactivity evaluation of essential oils from Thymus serpyllum, Thymus algeriensis and Thymus vulgaris were performed. GC/MS analysis revealed thymol as a major component of T. algeriensis, T. vulgaris and T. serpyllum, with its contribution to the oil 56.0%, 48.9% and 38.5%, respectively. All three essential oils (EOs) exhibited a significant antimicrobial activity against all tested strains, the T. serpyllum oil being the most potent one (MIC 2.5-5 mu g/mL, MBC 5-10 mu g/mL; MIC 1-2 mu g/mL, MFC 2-4 mu g/mL). In addition, the T. serpyllum oil revealed the highest antioxidant activity in all conducted assays and it was the most effective one against all tested cell lines, presenting GI(50) values of 7.02-52.69 mu g/mL. Moreover, none of the EOs showed toxicity at tested concentrations (>400 mu g/mL) for porcine liver primary cell culture. In addition to their well-known traditional use in food and cosmetics, the great potential of tested Thymus essential oils for application in oral diseases and anticancer treatments, encourage further investigation.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.rightsrestrictedAccess
dc.sourceIndustrial Crops & Products
dc.subjectT. serpyllumen
dc.subjectT. algeriensisen
dc.subjectT. vulgarisen
dc.subjectEssential oilsen
dc.subjectChemical compositionen
dc.subjectCytotoxicen
dc.subjectAntioxidanten
dc.subjectAntimicrobial activityen
dc.titleChemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oilsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСоковић, Марина; Гиwели, Aбдулхамед; Гламочлија, Јасмина; Фернандес, Aнгела; Марковић, Дејан; Цалхелха, Рицардо Ц.; Марковић, Татјана; Николић, Милош; Ферреира, Исабел Ц. Ф. Р.;
dc.citation.volume52
dc.citation.spage183
dc.citation.epage190
dc.citation.other52: 183-190
dc.citation.rankM21
dc.identifier.wos000332189200026
dc.identifier.doi10.1016/j.indcrop.2013.10.006
dc.identifier.scopus2-s2.0-84887650050
dc.identifier.rcubconv_3149
dc.type.versionpublishedVersion


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