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dc.creatorMiletić, Maja
dc.creatorMojsilović, S.
dc.creatorOkic-Đorđević, Ivana
dc.creatorKukolj, Tamara
dc.creatorJauković, Aleksandra
dc.creatorSantibanez, J. F.
dc.creatorJovcić, Gordana
dc.creatorBugarski, Diana
dc.date.accessioned2020-07-02T12:54:27Z
dc.date.available2020-07-02T12:54:27Z
dc.date.issued2014
dc.identifier.issn0354-4664
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1951
dc.description.abstractMesenchymal stem cells (MSCs) were isolated from human periodontal ligament (hPDL-MSCs) and characterized by their morphology, clonogenic efficiency, proliferation and differentiation capabilities. hPDL-MSCs, derived from normal impacted third molars, possessed all of the properties of MSC, including clonogenic ability, high proliferation rate and multi-lineage (osteogenic, chondrogenic, adipogenic, myogenic) differentiation potential. Moreover, hPDL-MSCs expressed a typical MSC epitope profile, being positive for mesenchymal cell markers (CD44H, CD90, CD105, CD73, CD29, Stro-1, fibronectin, vimentin, alpha-SMA), and negative for hematopoietic stem cell markers (CD34, CD11b, CD45, Glycophorin-CD235a). Additionally, hPDL-MSCs, as primitive and highly multipotent cells, showed high expression of embryonic markers (Nanog, Sox2, SSEA4). The data obtained provided yet further proof that cells with mesenchymal properties can be obtained from periodontal ligament tissue. Although these cells should be further investigated to determine their clinical significance, hPDL-MSCs are believed to provide a renewable and promising cell source for new therapeutic strategies in the treatment of periodontal defects.en
dc.publisherSrpsko biološko društvo, Beograd, i dr.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41011/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArchives of Biological Sciences
dc.subjectPeriodontal ligamenten
dc.subjectmesenchymal stem cellsen
dc.subjectcharacterizationen
dc.subjectproliferationen
dc.subjectdifferentiationen
dc.subjecttissue regenerationen
dc.titleMesenchymal stem cells isolated from human periodontal ligamenten
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractОкиц-Ђорђевић, Ивана; Сантибанез, Ј. Ф.; Мојсиловић, С.; Јауковић, Aлександра; Милетић, Маја; Кукољ, Тамара; Јовцић, Гордана; Бугарски, Диана;
dc.citation.volume66
dc.citation.issue1
dc.citation.spage261
dc.citation.epage271
dc.citation.other66(1): 261-271
dc.citation.rankM23
dc.identifier.wos000330552400035
dc.identifier.doi10.2298/ABS1401261M
dc.identifier.scopus2-s2.0-84892417888
dc.identifier.fulltexthttp://smile.stomf.bg.ac.rs/bitstream/id/614/1946.pdf
dc.identifier.rcubconv_3142
dc.type.versionpublishedVersion


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