ObjectiveThe present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. Materials and MethodsSalivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. ResultsEnalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/withou...t DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. ConclusionsEnalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.
Keywords:
anti-hypertensive drugs / xerostomia / salivary flow rate / salivary total antioxidant capacity / diabetes mellitus type 2
TY - JOUR
AU - Đukić, Ljiljana
AU - Roganović, Jelena
AU - Brajović, Milan
AU - Bokonjić, Dejan
AU - Stojić, Dragica
PY - 2015
UR - https://smile.stomf.bg.ac.rs/handle/123456789/1961
AB - ObjectiveThe present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. Materials and MethodsSalivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. ResultsEnalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/without DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. ConclusionsEnalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.
PB - Wiley, Hoboken
T2 - Oral Diseases
T1 - The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity
VL - 21
IS - 5
SP - 619
EP - 625
DO - 10.1111/odi.12325
ER -
@article{
author = "Đukić, Ljiljana and Roganović, Jelena and Brajović, Milan and Bokonjić, Dejan and Stojić, Dragica",
year = "2015",
abstract = "ObjectiveThe present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. Materials and MethodsSalivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. ResultsEnalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/without DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. ConclusionsEnalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity",
volume = "21",
number = "5",
pages = "619-625",
doi = "10.1111/odi.12325"
}
Đukić, L., Roganović, J., Brajović, M., Bokonjić, D.,& Stojić, D.. (2015). The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity. in Oral Diseases
Wiley, Hoboken., 21(5), 619-625.
https://doi.org/10.1111/odi.12325
Đukić L, Roganović J, Brajović M, Bokonjić D, Stojić D. The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity. in Oral Diseases. 2015;21(5):619-625.
doi:10.1111/odi.12325 .
Đukić, Ljiljana, Roganović, Jelena, Brajović, Milan, Bokonjić, Dejan, Stojić, Dragica, "The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity" in Oral Diseases, 21, no. 5 (2015):619-625,
https://doi.org/10.1111/odi.12325 . .
