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dc.creatorĐukić, Ljiljana
dc.creatorRoganović, Jelena
dc.creatorBrajović, Milan
dc.creatorBokonjić, Dejan
dc.creatorStojić, Dragica
dc.date.accessioned2020-07-02T12:55:05Z
dc.date.available2020-07-02T12:55:05Z
dc.date.issued2015
dc.identifier.issn1354-523X
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/1961
dc.description.abstractObjectiveThe present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. Materials and MethodsSalivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. ResultsEnalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/without DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. ConclusionsEnalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS//
dc.rightsrestrictedAccess
dc.sourceOral Diseases
dc.subjectanti-hypertensive drugsen
dc.subjectxerostomiaen
dc.subjectsalivary flow rateen
dc.subjectsalivary total antioxidant capacityen
dc.subjectdiabetes mellitus type 2en
dc.titleThe effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБокоњић, Дејан; Ђукић, Љиљана; Брајовић, Милан; Рогановић, Јелена; Стојић, Драгица;
dc.citation.volume21
dc.citation.issue5
dc.citation.spage619
dc.citation.epage625
dc.citation.other21(5): 619-625
dc.citation.rankM21
dc.identifier.wos000355741700010
dc.identifier.doi10.1111/odi.12325
dc.identifier.pmid25689395
dc.identifier.scopus2-s2.0-84930277109
dc.type.versionpublishedVersion


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