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dc.creatorRoganović, Jelena
dc.creatorĐukić, Ljiljana
dc.creatorKršljak, Elena
dc.creatorTanić, Nasta
dc.creatorStojić, Dragica
dc.date.accessioned2020-07-02T12:55:13Z
dc.date.available2020-07-02T12:55:13Z
dc.date.issued2015
dc.identifier.issn1354-523X
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/1963
dc.description.abstractObjectivesThe influence of experimental diabetes (alloxan, 100mgkg(-1)) was studied on rabbit parotid gland function. Material and MethodsCarbachol-induced parotid secretion in vivo, and in vitro quantification of inducible nitric oxide synthase (iNOS) mRNA expression, by real-time RT-PCR, and activity of superoxide dismutase (SOD) and total antioxidant capacity (TAC) in commercial colorimetric assays were measured in parotid glands of non-diabetic and diabetic rabbits. ResultsCarbachol-induced dose-dependent increase in parotid secretion significantly reduced in diabetic rabbits. Functional studies in the presence of muscarinic receptor and nitric oxide synthase (NOS) antagonists revealed that in M-3 receptor-mediated carbachol secretion, nitric oxide, deriving mainly from neuronal NOS (nNOS) in control, and iNOS in diabetic rabbits, was involved. Also, upregulation of iNOS mRNA expression and enhanced SOD activity and TAC were detected in diabetic glands. ConclusionsOur data suggest that decreased M-3 receptor-mediated parotid secretion in diabetic rabbits appears to be due to alterations in NO signaling, mainly due to iNOS induction, accompanied by elevated antioxidant response.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS//
dc.rightsrestrictedAccess
dc.sourceOral Diseases
dc.subjectdiabetesen
dc.subjectparotid secretionen
dc.subjectinducible nitric oxide synthaseen
dc.subjectoxidative stressen
dc.titleReduced muscarinic parotid secretion is underlain by impaired NO signaling in diabetic rabbitsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојић, Драгица; Рогановић, Јелена; Кршљак, Елена; Танић, Наста; Ђукић, Љиљана;
dc.citation.volume21
dc.citation.issue5
dc.citation.spage634
dc.citation.epage640
dc.citation.other21(5): 634-640
dc.citation.rankM21
dc.identifier.wos000355741700012
dc.identifier.doi10.1111/odi.12327
dc.identifier.pmid25703905
dc.identifier.scopus2-s2.0-84930276185
dc.identifier.rcubconv_3272
dc.type.versionpublishedVersion


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