HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients
Само за регистроване кориснике
2015
Аутори
Supić, GordanaKozomara, Ružica
Zeljić, Katarina
Stanimirović, Dragan
Magić, Marko
Surbatović, M.
Jović, N.
Magić, Zvonko
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined ov...er the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.
Кључне речи:
oral squamous cell carcinoma / oral lichen planus / high-mobility group box 1 / single nucleotide polymorphisms / recurrence-free survival / haplotypesИзвор:
Oral Diseases, 2015, 21, 4, 536-543Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Military Medical Academy, Belgrade, Serbia [06/10/A1]
DOI: 10.1111/odi.12318
ISSN: 1354-523X
PubMed: 25639284
WoS: 000353056900017
Scopus: 2-s2.0-84927694032
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Supić, Gordana AU - Kozomara, Ružica AU - Zeljić, Katarina AU - Stanimirović, Dragan AU - Magić, Marko AU - Surbatović, M. AU - Jović, N. AU - Magić, Zvonko PY - 2015 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1976 AB - ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC. PB - Wiley, Hoboken T2 - Oral Diseases T1 - HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients VL - 21 IS - 4 SP - 536 EP - 543 DO - 10.1111/odi.12318 ER -
@article{ author = "Supić, Gordana and Kozomara, Ružica and Zeljić, Katarina and Stanimirović, Dragan and Magić, Marko and Surbatović, M. and Jović, N. and Magić, Zvonko", year = "2015", abstract = "ObjectivesThis study examined the single nucleotide polymorphisms (SNPs) in high-mobility group box 1 (HMGB1) gene in patients with oral squamous cell carcinoma (OSCC) and oral lichen planus (OLP). Materials and methodsThe study was conducted on 93 patients with OSCC, 53 patients with OLP, and 100 controls, all Caucasians of the same ethnicity, matched by age. HMGB1 genotypes for 4 SNPs, 2262G/A (rs1045411), 1177G/C (rs3742305), 3814C/G (rs2249825), and rs4540927, were assessed using TaqMan SNP Genotyping Assays, Applied Biosystems. ResultsThe HMGB1 1177GG genotype was associated with lymph-node metastasis and tumor stage in OSCCs (P=0.016 and P=0.030, respectively). Genotype 1177GG resulted in poorer recurrence-free survival (RFS), P=0.000. The 1177G/C polymorphism was an independent predictor of RFS compared to GG genotype, P=0.001. The three polymorphisms were in linkage disequilibrium (LD). The AGC and GGC haplotypes were associated with an increased oral cancer risk, determined over the haplotype odds ratios (HOR=13.316, P=0.015, and HOR=5.769, P=0.029, respectively). The AGC haplotype was related to erosive OLP progression to OSCC (HOR=12.179, P=0.001). ConclusionsHMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.", publisher = "Wiley, Hoboken", journal = "Oral Diseases", title = "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients", volume = "21", number = "4", pages = "536-543", doi = "10.1111/odi.12318" }
Supić, G., Kozomara, R., Zeljić, K., Stanimirović, D., Magić, M., Surbatović, M., Jović, N.,& Magić, Z.. (2015). HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases Wiley, Hoboken., 21(4), 536-543. https://doi.org/10.1111/odi.12318
Supić G, Kozomara R, Zeljić K, Stanimirović D, Magić M, Surbatović M, Jović N, Magić Z. HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients. in Oral Diseases. 2015;21(4):536-543. doi:10.1111/odi.12318 .
Supić, Gordana, Kozomara, Ružica, Zeljić, Katarina, Stanimirović, Dragan, Magić, Marko, Surbatović, M., Jović, N., Magić, Zvonko, "HMGB1 genetic polymorphisms in oral squamous cell carcinoma and oral lichen planus patients" in Oral Diseases, 21, no. 4 (2015):536-543, https://doi.org/10.1111/odi.12318 . .