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Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome

Authorized Users Only
2015
Authors
Perić, Tamara
Marković, Dejan
Petrović, Bojan
Radojević, Vesna J.
Todorović, Tatjana
Anđelski-Radičević, Biljana
Jančić-Heinemann, Radmila M.
Susić, Gordana
Peri'-Popadić, Aleksandra
Tomić-Spirić, Vesna
Article (Published version)
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Abstract
The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a sli...ght increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.

Keywords:
Casein phosphopeptide-amorphous calcium phosphate / Casein phosphopeptide-amorphous calcium fluoride phosphate / Sjogren's syndrome / Saliva / Dental plaque / Enamel remineralisation
Source:
Clinical Oral Investigations, 2015, 19, 9, 2153-2165
Publisher:
  • Springer Heidelberg, Heidelberg

DOI: 10.1007/s00784-015-1444-1

ISSN: 1432-6981

PubMed: 25762499

WoS: 000365519800001

Scopus: 2-s2.0-84948113270
[ Google Scholar ]
11
8
URI
https://smile.stomf.bg.ac.rs/handle/123456789/1998
Collections
  • Radovi istraživača
Institution/Community
Stomatološki fakultet
TY  - JOUR
AU  - Perić, Tamara
AU  - Marković, Dejan
AU  - Petrović, Bojan
AU  - Radojević, Vesna J.
AU  - Todorović, Tatjana
AU  - Anđelski-Radičević, Biljana
AU  - Jančić-Heinemann, Radmila M.
AU  - Susić, Gordana
AU  - Peri'-Popadić, Aleksandra
AU  - Tomić-Spirić, Vesna
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1998
AB  - The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome
VL  - 19
IS  - 9
SP  - 2153
EP  - 2165
DO  - 10.1007/s00784-015-1444-1
ER  - 
@article{
author = "Perić, Tamara and Marković, Dejan and Petrović, Bojan and Radojević, Vesna J. and Todorović, Tatjana and Anđelski-Radičević, Biljana and Jančić-Heinemann, Radmila M. and Susić, Gordana and Peri'-Popadić, Aleksandra and Tomić-Spirić, Vesna",
year = "2015",
abstract = "The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome",
volume = "19",
number = "9",
pages = "2153-2165",
doi = "10.1007/s00784-015-1444-1"
}
Perić, T., Marković, D., Petrović, B., Radojević, V. J., Todorović, T., Anđelski-Radičević, B., Jančić-Heinemann, R. M., Susić, G., Peri'-Popadić, A.,& Tomić-Spirić, V.. (2015). Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 19(9), 2153-2165.
https://doi.org/10.1007/s00784-015-1444-1
Perić T, Marković D, Petrović B, Radojević VJ, Todorović T, Anđelski-Radičević B, Jančić-Heinemann RM, Susić G, Peri'-Popadić A, Tomić-Spirić V. Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome. in Clinical Oral Investigations. 2015;19(9):2153-2165.
doi:10.1007/s00784-015-1444-1 .
Perić, Tamara, Marković, Dejan, Petrović, Bojan, Radojević, Vesna J., Todorović, Tatjana, Anđelski-Radičević, Biljana, Jančić-Heinemann, Radmila M., Susić, Gordana, Peri'-Popadić, Aleksandra, Tomić-Spirić, Vesna, "Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome" in Clinical Oral Investigations, 19, no. 9 (2015):2153-2165,
https://doi.org/10.1007/s00784-015-1444-1 . .

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