Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high as...sociation of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.
Keywords:
CMV / IL-6 / immunohistochemistry / salivary gland cancer
TY - JOUR
AU - Radunović, Milena
AU - Tomanović, Nada
AU - Novaković, Ivana
AU - Boričić, Ivan
AU - Milenković, Sanja
AU - Dimitrijević, Milovan
AU - Radojević-Škodrić, Sanja
AU - Bogdanović, Ljiljana
AU - Basta-Jovanović, Gordana
PY - 2016
UR - https://smile.stomf.bg.ac.rs/handle/123456789/2077
AB - Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.
PB - Balkan Union of Oncology (B.U.ON.)
T2 - Journal of BUON
T1 - Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer
VL - 21
IS - 6
SP - 1530
EP - 1536
UR - https://hdl.handle.net/21.15107/rcub_smile_2077
ER -
@article{
author = "Radunović, Milena and Tomanović, Nada and Novaković, Ivana and Boričić, Ivan and Milenković, Sanja and Dimitrijević, Milovan and Radojević-Škodrić, Sanja and Bogdanović, Ljiljana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer",
volume = "21",
number = "6",
pages = "1530-1536",
url = "https://hdl.handle.net/21.15107/rcub_smile_2077"
}
Radunović, M., Tomanović, N., Novaković, I., Boričić, I., Milenković, S., Dimitrijević, M., Radojević-Škodrić, S., Bogdanović, L.,& Basta-Jovanović, G.. (2016). Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(6), 1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077
Radunović M, Tomanović N, Novaković I, Boričić I, Milenković S, Dimitrijević M, Radojević-Škodrić S, Bogdanović L, Basta-Jovanović G. Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON. 2016;21(6):1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077 .
