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dc.creatorUnic-Stojanović, Dragana
dc.creatorIsenović, Esma R.
dc.creatorJović, Miomir
dc.creatorMaravić-Stojković, Vera
dc.creatorMiljković, Milica
dc.creatorGojković, Tamara
dc.creatorMiličić, Biljana
dc.creatorBogdanović, Nikola
dc.creatorRadak, Đorđe
dc.date.accessioned2020-07-02T13:03:24Z
dc.date.available2020-07-02T13:03:24Z
dc.date.issued2016
dc.identifier.issn0003-3197
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2093
dc.description.abstractCopeptin is a sensitive and more stable surrogate marker for arginine vasopressin. In this study, we evaluated copeptin levels in carotid endarterectomy (CEA) patients, perioperatively, to determine whether copeptin levels can be related to carotid artery cross clamping (CC) time and to postoperative neurological outcomes. Copeptin, interleukin 6, C-reactive protein, cortisol, and brain natriuretic peptide were measured preoperatively (T1) and 3 hours postoperatively (T3) as well as intraoperatively (T2). We recruited 77 patients. Values of copeptin rose gradually over the observed times: T1 = 7.9 (6.4-9.6), T2 = 12.6 (9.3-16.8), and T3 = 72.3 (49.1-111.2) pmol/L. There was a significant difference for repeated measurement (P = .000, P = .000, and P = .000). Duration of carotid artery CC during CEA does not affect postoperative copeptin level (CC 13 minutes: 106.8 +/- 93.6 pmol/L, CC > 13 minutes: 96.7 +/- 89.1 pmol/L; P = .634). Preoperative copeptin level was significantly higher in patients with ulcerated plaque morphology. Activation of the stress axis in patients undergoing CEA results in copeptin elevation. Duration of CC during CEA does not affect postoperative copeptin levels.en
dc.publisherSage Publications Inc, Thousand Oaks
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.rightsrestrictedAccess
dc.sourceAngiology
dc.subjectcopeptinen
dc.subjectcarotid endarterectomyen
dc.subjectcross clampingen
dc.subjectstress responseen
dc.titleCopeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesiaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБогдановић, Никола; Радак, Ђорђе; Униц-Стојановић, Драгана; Исеновић, Есма Р.; Јовић, Миомир; Миљковић, Милица; Гојковић, Тамара; Маравић-Стојковић, Вера; Миличић, Биљана;
dc.citation.volume67
dc.citation.issue10
dc.citation.spage951
dc.citation.epage960
dc.citation.other67(10): 951-960
dc.citation.rankM22
dc.identifier.wos000386036600011
dc.identifier.doi10.1177/0003319716629322
dc.identifier.pmid26843542
dc.identifier.scopus2-s2.0-84990855378
dc.identifier.rcubconv_3396
dc.type.versionpublishedVersion


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